Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas

Inclusion Criteria:

- Age ≥ 18 years

- Suspected glioma (grade II, III, or IV)

- Preoperative MR perfusion (enhancing tumors)

- Preoperative MR 2-HG spectroscopy (nonenhancing tumors)Patient indicated for surgical
resection, standard radiation, and standard chemotherapy as a standard of care

- Karnofsky performance status ≥ 60

- Life expectancy > 12 weeks

- Ability to comply with study and follow-up procedures

Exclusion Criteria:

- Prior diagnosis of intracranial glioma

- Other malignancy with expected need for systemic therapy within 3 years

- Inability to have 6000 grays of radiation to the brain

- Need for urgent palliative intervention for primary disease (e.g., impending
herniation)

- Evidence of bleeding diathesis or coagulopathy

- History of intracerebral abscess within 6 months prior to Day 0

- Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
prior to Day 0, anticipation of need for major surgical procedure during the course of
the study

- Pregnant or nursing females

- Subjects unable to undergo an MRI with contrast