Targeted Imaging of Glutamate Carboxypeptidase II With DCFPyL-PET

The purpose of this protocol is to extend our existing patient base from those with prostate
cancer to those with any solid malignancy - as well as patients with schwannoma, a
non-malignant solid tumor that also over-expresses GCP II. Using our first generation imaging
agent, [18F]DCFBC, we have shown that we could detect GCP II in tissue specimens of patients
with a variety of cancers, and vestibular schwannoma. We have also shown that GCP II may not
only be present in the neovasculature of solid (non-prostate) tumors, but also reside within
the tumor epithelium itself. We have shown that to be the case for melanoma, in particular.
Our goal is to leverage the broad utility of our GCP II targeted imaging agents for managing
other cancers. In addition to schwannoma, the cancers we intend to target include but will
not be restricted to: head and neck cancer, salivary gland tumors, renal cell carcinoma,
transitional cell carcinoma, colorectal cancer, gastric cancer, neuroendocrine cancer,
glioblastoma, melanoma, pancreatic cancer, non-small cell lung cancer, soft tissue sarcoma,
breast cancer, endometrial cancer, ovarian cancer, lymphoma and multiple myeloma.

Inclusion Criteria:

1. Greater than or equal to 18 years of age

2. Biopsy-proven cancer or Schwannoma diagnosis

3. No contraindications to PET scanning to include pregnancy, etc. For females of
childbearing potential, negative serum pregnancy test obtained within a 10-day period
prior to PET study

4. Patients or their legal representatives must have the ability to read, understand and
provide written informed consent for the initiation of any study related procedures.

Exclusion Criteria:

1. Administered a radioisotope within 5 physical half-lives prior to PET imaging

2. In female subjects pregnancy.