High-Shear Microfluidic Thrombosis Assay
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Hematology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Hematology |
| Healthy: | No |
| Age Range: | 45 - Any |
| Updated: | 6/9/2018 |
| Start Date: | May 2015 |
| End Date: | October 2015 |
Characterization of a Novel High-Shear Thrombosis Assay in Normal and Aspirin-treated Patients
The purpose of this study is to characterize a new test to assess the rate and time it takes
to form a blood clot in people who either do or do not take aspirin.
to form a blood clot in people who either do or do not take aspirin.
It is estimated that approximately 25% of people are resistant to aspirin, or do not respond
to its effect. These individuals have a four fold higher risk of a heart attack or stroke
compared to those who respond to aspirin. Current tests for determining those who are aspirin
resistant are not reliable. This study is assessing the effectiveness of a new assay in
determining the rate and time it takes for people who are or are not on aspirin in forming a
blood clot.
to its effect. These individuals have a four fold higher risk of a heart attack or stroke
compared to those who respond to aspirin. Current tests for determining those who are aspirin
resistant are not reliable. This study is assessing the effectiveness of a new assay in
determining the rate and time it takes for people who are or are not on aspirin in forming a
blood clot.
Inclusion Criteria for "no aspirin" group:
- have not taken aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs), or
clopidogrel in the previous 10 days
- no history of myocardial infarction, ischemic stroke, or other ischemic event
Inclusion Criteria for "aspirin daily" group:
- have taken aspirin daily over the last 10 days or more
- no history of myocardial infarction, ischemic stroke, or other ischemic event
Inclusion Criteria for "new to aspirin" group:
- have not previously been prescribed aspirin, but have been prescribed aspirin at their
present appointment, e.g. a high calcium plaque score on CT
- no history of myocardial infarction, ischemic stroke, or other ischemic event
Exclusion Criteria:
- a known bleeding or thrombotic disorder
Exclusion Criteria for "new to aspirin" group:
- a known bleeding or thrombotic disorder
- have taken aspirin, other NSAIDs, clopidogrel, or an anticoagulant in the previous 10
days
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