Self-Management Program and Survivorship Care Plan in Improving the Health of Cancer Survivors After Stem Cell Transplant

PRIMARY OBJECTIVES:

I. Determine whether 2-5 year hematopoietic cell transplant (HCT) survivors with elevated
cancer-related distress or poor health care adherence, adherence to cardiometabolic or
subsequent malignancy surveillance who are randomized to receive the online,
patient-centered, self-management stepped care program will report reduced distress, and
improved health care adherence for cardiometabolic or subsequent malignancy surveillance at
12 months when compared with an active control group who receive access to HCT survivorship
best practices.

II. Determine characteristics of intervention participants who require telehealth stepped
care at 6-week, because they 1) do not meet criteria for adequate knowledge of subsequent
malignancy and cardiometabolic risks, or 2) do not report improved distress, or 3) have not
logged in to the online program.

III. Determine resources that would be needed to sustain the intervention as a national HCT
survivorship program if implemented through the Center for International Blood and Marrow
Transplant Research (CIBMTR)/National Marrow Donor Program (NMDP).

SECONDARY OBJECTIVES:

I. Process measures of internet study reach and utilization, as well as depression, physical
function, physical activity level, and knowledge of survivorship needs in HCT survivors.

OUTLINE: Patients are randomized to 1 of 2 groups.

GROUP I: Patients receive immediate access to the INSPIRE online program and personalized
survivorship care plan.

GROUP II: Patients receive an online program linking to existing online survivor resources
and a personalized survivorship care plan. Patients may receive access to the INSPIRE online
program after 12 months.

Inclusion Criteria:

- Received >= 1 autologous or allogeneic (related or unrelated) HCT with curative intent
at a participating transplant center for a hematologic malignancy

- Age 18 years of age or older at last transplant

- Survival 2-5 years after last HCT when first approached for enrollment

- In remission at time of study entry, may be receiving chemoprevention

- Internet and email access

- American and Canadian citizens, and/or those with mailing addresses in the US/Canada
and/or temporarily residing anywhere outside the country (IE — military).

Exclusion Criteria:

- Development of invasive subsequent malignancy after HCT other than non-melanoma skin
cancer, in the past two years

- Medical or other issue prohibiting computer use, reading or ability to comply with all
study procedures or unable to communicate via phone (e.g., significant vision, hearing
or cognitive impairment, major illness, hospitalization)

- Residing in an institution or other living situation where health care decisions are
not made by the participant (e.g., hospitalized, prisoners, living in a rehabilitation
facility)

- Does not complete baseline patient-reported outcome (PRO) assessment items required to
determine stratification or whether the survivor meets inclusion and exclusion
criteria

- Non-proficient in English (written and spoken)