The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients
| Status: | Recruiting |
|---|---|
| Conditions: | Arthritis |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 18 - 30 |
| Updated: | 4/6/2019 |
| Start Date: | April 1, 2019 |
| End Date: | December 31, 2022 |
| Contact: | Jennifer Hledik, PhD |
| Email: | jerhart@stanford.edu |
| Phone: | 650-493-5000 |
Novel Strategies to Combat Post-Traumatic Osteoarthritis (PTOA):The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients
This project addresses the clinical need for effective treatments to delay or prevent the
development of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL)
injury. Despite the high prevalence of OA, there are currently no treatments to modify the
course of the disease, and treatment is aimed at alleviation of symptoms. This project will
investigate a pharmacological treatment (Tranexamic Acid) early after ACL injury on altering
inflammation and cartilage degeneration following ACL injury as a new strategy to prevent or
delay the onset of PTOA.
development of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL)
injury. Despite the high prevalence of OA, there are currently no treatments to modify the
course of the disease, and treatment is aimed at alleviation of symptoms. This project will
investigate a pharmacological treatment (Tranexamic Acid) early after ACL injury on altering
inflammation and cartilage degeneration following ACL injury as a new strategy to prevent or
delay the onset of PTOA.
Inclusion Criteria:
- age 18-30 years
- within 4 days of unilateral ACL injury
- presence of effusion/hemarthrosis.
Exclusion Criteria:
- inflammatory arthritis, radiographic osteoarthritis (K-L Grade 2 or higher), gout/
pseudogout
- systemic or acute illness requiring medications
- concomitant knee injury aside from meniscus tear and MCL tear not requiring surgery
- prior surgery to either knee
- prior injury to either knee requiring crutches
- history of thromboembolic disease
- current use of combination hormonal contraception
- chronic NSAID use
- cortisone injection to either knee within the prior 3 months
- not indicated for or unable to undergo ACLR within 3 months of injury
We found this trial at
1
site
Stanford University Stanford University, located between San Francisco and San Jose in the heart of...
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