EEG Studies of Ketamine General Anesthesia
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 1/10/2019 |
| Start Date: | November 1, 2018 |
| End Date: | November 2019 |
| Contact: | Oluwaseun Johnson-Akeju, M.D., M.M.Sc. |
| Email: | oluwaseun.akeju@mgh.harvard.edu |
| Phone: | 617-724-7200 |
Electroencephalogram Studies of Induction and Recovery From Ketamine-Induced General Anesthesia
We are doing this research study to find out how and where ketamine acts in the brain.
Ketamine is an anesthetic (a drug or agent used to decrease or eliminate the feeling of pain
by putting you in an unconscious state). We will look at the brain using a machine that
records the brain's electrical activity, called an electroencephalogram (EEG).
Ketamine is an anesthetic (a drug or agent used to decrease or eliminate the feeling of pain
by putting you in an unconscious state). We will look at the brain using a machine that
records the brain's electrical activity, called an electroencephalogram (EEG).
In this trial, participants will be given ketamine at a high enough dosage to induce general
anesthesia. EEG recording will be conducted during this time. Cognitive assessments, computer
tasks and pain monitoring will be administered.
anesthesia. EEG recording will be conducted during this time. Cognitive assessments, computer
tasks and pain monitoring will be administered.
Inclusion Criteria:
- Between the ages of 18 to 45
- Normal body weight and habitus, BMI less than or equal to 30
- Non-smoker
- American Society of Anesthesiologists (ASA) physical status classification P1
Exclusion Criteria:
- Cardiovascular: myocardial infarction, coronary artery disease, peripheral vascular
disease, arrhythmia, congestive heart failure, valvular disease, hypertension
- Respiratory: bronchitis, chronic obstructive pulmonary disease, smoking, shortness of
breath
- Hepatic: hepatitis, jaundice, ascites
- Neurologic: seizure, stroke, positive neurologic findings on neurologic examination,
multiple sclerosis, Meniere's disease, Parkinson's disease, neuropathy, peripheral
stenosis
- Gastrointestinal: esophageal reflux, hiatal hernia, ulcer
- Endocrine: diabetes, thyroid disease
- Renal: acute or chronic severe renal insufficiency
- Hematologic: blood dyscrasias, anemia, coagulopathies, on anticoagulant therapy
- Musculoskeletal: prior surgery or trauma to head neck or face, arthritis, personal or
family history of malignant hyperthermia
- Psychiatric: history or treatment for an active psychiatric problem, depression
- Reproductive: pregnancy, breast-feeding
- Medications: regular use of prescription and non-prescription medications expected to
affect CNS function, St. John's Wort
- Allergies: labetalol, ondansetron, glycopyrrolate, ketamine, midazolam
We found this trial at
1
site
185 Cambridge Street
Boston, Massachusetts 02114
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Oluwaseun Johnson-Akeju, M.D.,M.M.Sc.
Phone: 617-724-7200
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