ARV Concentrations in Hair
| Status: | Completed |
|---|---|
| Conditions: | HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/15/2018 |
| Start Date: | April 1, 2016 |
| End Date: | January 30, 2017 |
IGHID 11601 - Measuring Antiretroviral Concentrations in Hair
Hair samples from subjects on antiretroviral therapy, both HIV- and HIV+ patients with HIV
RNA <50copies/mL for >6 months will be analyzed to investigate the influence of race, hair
color and hair treatment on ARV response.
RNA <50copies/mL for >6 months will be analyzed to investigate the influence of race, hair
color and hair treatment on ARV response.
A small thatch of hair (approximately 20 strands) will be collected from 85 participants who
are currently taking antiretrovirals (ARVs). Hair collection will be evenly distributed into
color cohorts: Black, Brown, Blonde and Grey. Participants will need to be >80% adherent to
their medication and have had an undetectable HIV RNA VL within the previous 6 months. In the
lab, samples will be used to develop IR-MALDESI MSI hair protocols for high sensitivity and
accuracy to quantify ARVs in 5 therapeutic drug classes (Integrase Inhibitors, Nucleoside
Reverse Transcriptase Inhibitors, Non-Nucleoside Reverse Transcriptase Inhibitors, Entry
Inhibitors, Protease Inhibitors).
are currently taking antiretrovirals (ARVs). Hair collection will be evenly distributed into
color cohorts: Black, Brown, Blonde and Grey. Participants will need to be >80% adherent to
their medication and have had an undetectable HIV RNA VL within the previous 6 months. In the
lab, samples will be used to develop IR-MALDESI MSI hair protocols for high sensitivity and
accuracy to quantify ARVs in 5 therapeutic drug classes (Integrase Inhibitors, Nucleoside
Reverse Transcriptase Inhibitors, Non-Nucleoside Reverse Transcriptase Inhibitors, Entry
Inhibitors, Protease Inhibitors).
Inclusion Criteria:
- HIV Negative or HIV positive individuals, aged 18 years or older, who have been taking
their ARV medication for at least 3 months and are adherent based on blood plasma HIV
RNA of <50 copies/mL or HIV negative status.
Exclusion Criteria:
- Subjects non-adherent to anti-retroviral regimen
- Subjects not willing or able to provide head hair sample
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