Characterization of the Neo-squamous Epithelial Barrier
| Status: | Recruiting |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 2/9/2019 |
| Start Date: | September 26, 2016 |
| End Date: | December 2020 |
| Contact: | Michele L Johnson, CCRP |
| Email: | johnson.michele@mayo.edu |
| Phone: | 507-255-8692 |
Prospective Characterization of the Neo-squamous Epithelial Barrier Following Successful Endoscopic Therapy in Barrett's Esophagus
To prospectively assess the functional aspects of the the esophageal squamous epithelial
barrier and correlate this with tissue inflammation and intercellular space dilation in
patients who have successfully completed endoscopic radiofrequency ablation versus balloon
cryotherapy for Barrett's Esophagus related metaplasia.
barrier and correlate this with tissue inflammation and intercellular space dilation in
patients who have successfully completed endoscopic radiofrequency ablation versus balloon
cryotherapy for Barrett's Esophagus related metaplasia.
The investigators will measure and correlate mucosal impedance (measured using a novel
endoscopic mucosal impedance catheter), intercellular space as measured with transmission
electron microscopy and tissue levels of prostaglandin E2 in patients undergoing surveillance
following successful endoscopic therapy (defined as two negative endoscopic surveillance
histology for intestinal metaplasia).
Mucosal impedance will be measured by an endoscopic probe. Research biopsies will also be
obtained for measurement of tissue levels of prostaglandin E2 and intracellular space with
transmission electron microscopy.
Volumetric laser endomicroscopy will measure the precise thickness of and area of subsquamous
structures underneath the neosquamous epithelium.
endoscopic mucosal impedance catheter), intercellular space as measured with transmission
electron microscopy and tissue levels of prostaglandin E2 in patients undergoing surveillance
following successful endoscopic therapy (defined as two negative endoscopic surveillance
histology for intestinal metaplasia).
Mucosal impedance will be measured by an endoscopic probe. Research biopsies will also be
obtained for measurement of tissue levels of prostaglandin E2 and intracellular space with
transmission electron microscopy.
Volumetric laser endomicroscopy will measure the precise thickness of and area of subsquamous
structures underneath the neosquamous epithelium.
Inclusion Criteria:
- Adults (age 18-90) who underwent an ablative program for BE
Exclusion Criteria:
- Patients that have not achieved complete remission of intestinal metaplasia.
- Patients unable to consent.
- Pregnant women
We found this trial at
2
sites
630 W 168th St
New York, New York
New York, New York
212-305-2862
Phone: 212-304-5595
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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