Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking

Smoking is the leading cause of preventable death in the United States. An FDA-mandated
reduction in the nicotine content of cigarettes might reduce the health burden of tobacco by
reducing the prevalence of smoking. The proposed project will test the impact of nicotine
reduction on smoking behavior and smoke exposure in a setting where participants are
restricted from using their usual brand cigarettes.Smokers will be confined to a hotel for
two hotel stays (five days/ four nights each) during which they will only have access to the
investigational cigarettes provided to them. The nicotine content of the investigational
cigarettes may differ between the two weeks. Participants will enter the hotel in groups of
10 and everyone in a given stay will receive the same investigational cigarette. The first
aim will assess measures of smoke and nicotine exposure including urinary cotinine and
expired carbon monoxide. The second aim will assess behavioral measures of smoking including
cigarettes smoked per day and puff topography.

Inclusion Criteria:

- male or female participants who are least 18 years old and smoke daily

- willing to stay in a hotel for two four-night stays during the prearranged dates

Exclusion Criteria:

- unwilling to use research cigarettes as part of the trial

- pregnant, trying to become pregnant, or breastfeeding

- additional smoking and health criteria determined at screening