Magnetic Resonance Spectroscopy (MRS) Validation Study in Individuals With Nonalcoholic Fatty Liver Disease (NAFLD)



Status:Completed
Conditions:Gastrointestinal, Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 65
Updated:6/17/2018
Start Date:June 2009
End Date:March 2010

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Trial Summary
Trial Overview
Inclusion Criteria

MRS Validation Study of Hepatic Triglyceride Content in Non-alcoholic Fatty Liver Disease (NAFLD)Subjects Pre- and Post-Prandial

The purpose of this study is to see how effective the investigators' optimized magnetic
resonance spectroscopy (MRS) sequence in quantifying hepatic triglyceride content (HTGC) to
enhance MRS as a diagnostic tool in non-alcohol fatty liver disease (NAFLD).

One way to gauge MRS as an effective diagnostic tool is by looking at the reproducibility of
the liver fat measurements on subjects by calculating the coefficient of variation (CV). This
study assesses the modified MRS sequence, using both breath holds and free breathing. The
HTGC levels are measured twice in the same individuals on two independent events separated by
10 minutes. Subjects are then given a high fat, high carbohydrate meal of Pizza Hut pizza,
Pepsi, and Oreo cookies. Two hours after eating the meal, the subjects return to the scanner
and repeat all MRS scans.

Inclusion Criteria:

- Obese

Exclusion Criteria:

- Diabetes

- Pregnant
We found this trial at
1
site
Barnes Jewish Hospital
Saint Louis, Missouri 63110
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mi
from
Saint Louis, MO
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