Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 40 - 90 |
| Updated: | 6/17/2018 |
| Start Date: | November 2015 |
| End Date: | February 2017 |
The purpose of this study is to investigate antibiotic treatment to target bacteria about the
shoulder. This bacteria, Propionibacterium acnes, is detected in many revision shoulder
surgeries and is thought to contribute to periprosthetic joint infections, pain, and failure
of total shoulder arthroplasty as well as other shoulder surgeries. This study is
investigating adding an FDA approved antibiotic that is commonly used for treatment of this
bacteria and many common infections. The investigators will take intraoperative cultures to
look for the presence or absence of specific bacteria. The investigators are conducting this
trial to see if adding another antibiotic to specifically target this common bacteria found
around the shoulder will be effective.
shoulder. This bacteria, Propionibacterium acnes, is detected in many revision shoulder
surgeries and is thought to contribute to periprosthetic joint infections, pain, and failure
of total shoulder arthroplasty as well as other shoulder surgeries. This study is
investigating adding an FDA approved antibiotic that is commonly used for treatment of this
bacteria and many common infections. The investigators will take intraoperative cultures to
look for the presence or absence of specific bacteria. The investigators are conducting this
trial to see if adding another antibiotic to specifically target this common bacteria found
around the shoulder will be effective.
Patients undergoing total and reverse shoulder arthroplasty for primary glenohumeral
arthritis will be invited to participate in this study if patients meet inclusion and
exclusion criteria. Patients will be randomized to receive either standard perioperative
antibiotics with cefazolin or to the treatment group to receive doxycycline in addition to
cefazolin. Patients will then undergo routine surgical treatment. 3 cultures from the
superficial tissue, dermis, and glenohumeral joint will be taken and cultured for 14 days to
detect any bacterial growth.
arthritis will be invited to participate in this study if patients meet inclusion and
exclusion criteria. Patients will be randomized to receive either standard perioperative
antibiotics with cefazolin or to the treatment group to receive doxycycline in addition to
cefazolin. Patients will then undergo routine surgical treatment. 3 cultures from the
superficial tissue, dermis, and glenohumeral joint will be taken and cultured for 14 days to
detect any bacterial growth.
Inclusion Criteria:
- Patients undergoing primary total shoulder arthroplasty at Rush University Medical
Center
Exclusion Criteria:
- Patients with prior shoulder surgery of any kind
- Patients with a known infection or history of infection with clinical signs such as
elevated erythrocyte sedimentation rate, C-reactive protein, positive culture
aspiration
- Patients with a known allergy to doxycycline
- Patients with a known allergy to cefazolin or penicillin
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