A Trial of Hu5F9-G4 With Avelumab in Ovarian Cancer
| Status: | Recruiting |
|---|---|
| Conditions: | Ovarian Cancer, Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/6/2019 |
| Start Date: | May 24, 2018 |
| End Date: | May 2023 |
| Contact: | Gani Chico, MD |
| Email: | info@fortyseveninc.com |
| Phone: | (650) 352-4150 |
A Phase 1b Trial of Hu5F9-G4 in Combination With Avelumab in Solid Tumor Patients and Checkpoint Inhibitor Naïve Ovarian Cancer Patients Who Progress Within 6 Months of Prior Platinum Chemotherapy
This is an open label, multicenter, Phase 1b trial investigating the combination of Hu5F9 G4
and avelumab in patients with solid tumors and ovarian cancer.
and avelumab in patients with solid tumors and ovarian cancer.
Inclusion Criteria:
- Safety Run-in: Pathologically confirmed advanced solid tumors.
- Ovarian Cancer Expansion: Histologically or cytologically confirmed, epithelial
ovarian, fallopian tube, or peritoneal cancer.
- Ovarian Cancer Expansion: Checkpoint inhibitor naïve patients.
- Ovarian Cancer Expansion: Willing to consent to 1 mandatory pre treatment and 1
on-treatment tumor biopsy.
- Adequate performance status. Adequate hematological, liver, and kidney functions.
- Availability of pre-treatment tumor tisse to evaulate PD-L1 expression.
Exclusion Criteria:
- Patients with symptomatic or untreated central nervous system (CNS) metastases.
- Prior treatment with CD47 or SIRPα targeting agents.
- Known active or chronic hepatitis B or C infection or human immunodeficiency virus
(HIV).
- RBC transfusion dependence.
- Prior organ transplantation requiring immunosuppression or active autoimmune disease.
- Significant medical diseases and/or history of uncontrolled intercurrent illness or
other serious medical condition.
- Pregnancy or active breast feeding.
We found this trial at
6
sites
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University of Chicago One of the world's premier academic and research institutions, the University of...
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Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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University of Oklahoma The OU Health Sciences Center is composed of seven health-related colleges located...
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