Health Disparities in Hypertension
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 40 - 60 |
| Updated: | 2/8/2019 |
| Start Date: | December 1, 2018 |
| End Date: | July 1, 2022 |
| Contact: | Nicole P Bowles, PhD |
| Email: | bowlesn@ohsu.edu |
| Phone: | 5034942541 |
Sleep and Circadian Mechanisms Contributing to Disparity in Prevalence of Hypertension Between Black and White Americans
This study will be the first to distinguish the relative contributions of sleep, circadian
and behavioral mechanisms to the non-dipping BP profile in Black adults and will lay the
groundwork for optimizing therapies dependent on mechanisms, such as targeting sleep,
targeting circadian rhythmicity, or targeting behaviors, and raising the possibility that
ideal therapy for hypertension (HTN) may differ by race. This research will ultimately help
to improve health and survival in black populations with HTN.
and behavioral mechanisms to the non-dipping BP profile in Black adults and will lay the
groundwork for optimizing therapies dependent on mechanisms, such as targeting sleep,
targeting circadian rhythmicity, or targeting behaviors, and raising the possibility that
ideal therapy for hypertension (HTN) may differ by race. This research will ultimately help
to improve health and survival in black populations with HTN.
By studying standardized behaviors and regulators of BP during sleep and behavioral stresses
across all circadian phases, this protocol will allow us specifically to:
1. To determine if poor sleep, while controlling for circadian phase, contributes to the
higher overall BP and reduced nocturnal drop in BP in Blacks compared to Whites.
2. To determine if reduced BP responses to standardized behavioral changes across the day
and night contribute to the higher overall BP and reduced nocturnal drop in BP in Blacks
compared to Whites.
3. To determine if reduced circadian amplitude of BP contributes to the higher overall BP
and reduced nocturnal drop in BP in Blacks compared to Whites.
across all circadian phases, this protocol will allow us specifically to:
1. To determine if poor sleep, while controlling for circadian phase, contributes to the
higher overall BP and reduced nocturnal drop in BP in Blacks compared to Whites.
2. To determine if reduced BP responses to standardized behavioral changes across the day
and night contribute to the higher overall BP and reduced nocturnal drop in BP in Blacks
compared to Whites.
3. To determine if reduced circadian amplitude of BP contributes to the higher overall BP
and reduced nocturnal drop in BP in Blacks compared to Whites.
Inclusion Criteria:
- Self-identified Black or White
- 'normotensive' (resting systolic blood pressure (SBP) <140/90 mmHg) or uncomplicated
stage 1 'hypertensive' (systolic BP between 140 and 160 mmHg or a diastolic (DBP)
between 90 and 100 mmHg).
- free of all prescription and non-prescription drugs (including caffeine, nicotine,
alcohol and herbal medications)
Exclusion Criteria:
- Currently treated with pharmacologic agents for hypertension
- Blood pressure >160/100 mmHg
- Smoked within the last year
- Regular night work or rotating shift work for the three months prior to the study
- Travel across more than three time zones during the three months prior to the study.
- Any acute, chronic or debilitating medical conditions, other than mild hypertension
(140
- Moderate to severe obstructive sleep apnea (OSA)
- History of severe psychiatric illnesses or psychiatric disorders will be excluded,
including alcoholism, drug dependency, major depression, manic depressive illness,
schizophrenic disorders, panic disorder, generalized anxiety disorder, post-traumatic
stress disorder, agoraphobia, claustrophobia, paranoid personality disorder, schizoid
personality disorder, schizotypal personality disorder, borderline personality
disorder, and antisocial personality disorder.
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Phone: 503-494-2541
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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