Epidemiology of Sleep-Disordered Breathing in Adults
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Insomnia Sleep Studies, Peripheral Vascular Disease, Neurology, Psychiatric |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 30 - 95 |
| Updated: | 6/20/2018 |
| Start Date: | April 1999 |
| End Date: | April 2025 |
To characterize the natural history and biologic spectrum of sleep disordered breathing (SDB)
and other sleep problems and disorders, and test hypotheses regarding the causes and
consequences of SDB and other sleep problems and disorders.
and other sleep problems and disorders, and test hypotheses regarding the causes and
consequences of SDB and other sleep problems and disorders.
BACKGROUND:
Recent research has shown that sleep disordered breathing (SDB) is much more common than
previously thought. While it is known that in clinic samples, SDB is associated with
hypertension, cardiovascular disease and mortality, little is known about the natural history
of this disorder, particularly in the general population, nor about the causal role of known
risk factors. The knowledge obtained from the results of this study will help advance the
field of sleep disorders medicine. Information about longitudinal effects and causal
relationships may be applied to clinical situations, thus reducing the morbidity and
mortality associated with this disorder.
DESIGN NARRATIVE:
In this longitudinal study, follow-up polysomnography and other protocols are conducted on an
established cohort of men and women (age 30-60 years at the time of initial recruitment in
1989), currently enrolled in the Wisconsin Sleep Cohort Study. The study aims to : 1)
describe the natural history of SDB across middle and older age; 2) investigate associations
of SDB with early and intermediate markers of cardiovascular dysfunction, damage, and
cardiovascular disease; 3) investigate the longitudinal association of SDB in accelerated
cognitive decline; 4) investigate the association of SDB and adverse sleep characteristics
with age-related risk factors and outcomes.
Recent research has shown that sleep disordered breathing (SDB) is much more common than
previously thought. While it is known that in clinic samples, SDB is associated with
hypertension, cardiovascular disease and mortality, little is known about the natural history
of this disorder, particularly in the general population, nor about the causal role of known
risk factors. The knowledge obtained from the results of this study will help advance the
field of sleep disorders medicine. Information about longitudinal effects and causal
relationships may be applied to clinical situations, thus reducing the morbidity and
mortality associated with this disorder.
DESIGN NARRATIVE:
In this longitudinal study, follow-up polysomnography and other protocols are conducted on an
established cohort of men and women (age 30-60 years at the time of initial recruitment in
1989), currently enrolled in the Wisconsin Sleep Cohort Study. The study aims to : 1)
describe the natural history of SDB across middle and older age; 2) investigate associations
of SDB with early and intermediate markers of cardiovascular dysfunction, damage, and
cardiovascular disease; 3) investigate the longitudinal association of SDB in accelerated
cognitive decline; 4) investigate the association of SDB and adverse sleep characteristics
with age-related risk factors and outcomes.
Inclusion criteria:
- Employee of one of the 4 Wisconsin state agencies
- Age 30-60 in 1988
Exclusion criteria:
- Current pregnancy
- Unstable or decompensated cardiopulmonary disease
- Airway cancer
- Recent upper respiratory surgery
We found this trial at
1
site
600 Highland Ave
Madison, Wisconsin 53792
Madison, Wisconsin 53792
(608) 263-6400
University of Wisconsin Hospital and Clinics UW Health strives to meet the health needs of...
Click here to add this to my saved trials
