Effect of Olopatadine on Allergic Tear Mediators
| Status: | Completed |
|---|---|
| Conditions: | Allergy, Ocular |
| Therapuetic Areas: | Ophthalmology, Otolaryngology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 9/22/2018 |
| Start Date: | September 2000 |
| End Date: | November 2009 |
Expression of Inflammatory Mediators in Allergic Conjunctivitis
The purpose of the research is to determine which inflammatory substances are involved in
causing allergic symptoms in the eye. Allergic conjunctivitis is a common problem with
symptoms of temporary redness, itching, tearing, and swelling of the eyes. Substances
released by cells in the affected tissues cause allergic reactions in the eye and elsewhere
in the body.
causing allergic symptoms in the eye. Allergic conjunctivitis is a common problem with
symptoms of temporary redness, itching, tearing, and swelling of the eyes. Substances
released by cells in the affected tissues cause allergic reactions in the eye and elsewhere
in the body.
Ocular allergies are extremely common, affecting up to 80 million people in the USA. Our
research question is:
Are there differences in inflammatory mediators and cell surface activation markers in
patients undergoing seasonal allergic conjunctivitis compared to those with sight threatening
disease such as Atopic Keratoconjunctivitis (AKC) and will the use of the anti-allergy eye
drop, PATANOL® (olopatadine hydrochloride) affect these parameters?
Experimental Design:
Ocular surface cells (by impression cytology) and tears (via capillary tube) are collected
from allergic, non-allergic, and AKC subjects undergoing an reaction induced either by
seasonal allergen or topical allergen provocation (specificity and dose determined via skin
testing). Ocular surface cells are evaluated for surface activation markers. Tears are
evaluated for mediator content. Tears are also incubated with peripheral blood eosinophils
and lymphocytes to see effects on adhesion to conjunctival epithelial cells.
research question is:
Are there differences in inflammatory mediators and cell surface activation markers in
patients undergoing seasonal allergic conjunctivitis compared to those with sight threatening
disease such as Atopic Keratoconjunctivitis (AKC) and will the use of the anti-allergy eye
drop, PATANOL® (olopatadine hydrochloride) affect these parameters?
Experimental Design:
Ocular surface cells (by impression cytology) and tears (via capillary tube) are collected
from allergic, non-allergic, and AKC subjects undergoing an reaction induced either by
seasonal allergen or topical allergen provocation (specificity and dose determined via skin
testing). Ocular surface cells are evaluated for surface activation markers. Tears are
evaluated for mediator content. Tears are also incubated with peripheral blood eosinophils
and lymphocytes to see effects on adhesion to conjunctival epithelial cells.
Inclusion Criteria:
- Skin test positive
- Able to put drops in eyes
- Able to have tears collected
We found this trial at
1
site
Madison, Wisconsin 53792
(608) 263-2400
Principal Investigator: Neal P Barney, MD
Phone: 608-263-7681
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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