Effect of GLP-1 on Insulin Biosynthesis and Turnover Rates
| Status: | Completed |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/2/2016 |
| Start Date: | November 2007 |
| End Date: | November 2008 |
| Contact: | Cynthia Rivera, RN |
| Email: | carivera@aecom.yu.edu |
| Phone: | 718-430-2446 |
The gut hormone glucagon like peptide-1 (GLP-1) has been shown to have important effects on
maintaining the function and health of the insulin producing beta cells. This hormone is
known to increase the production rate of new insulin as well as increase the release of
insulin into the blood. We will measure the rate of new insulin production in subjects with
Type 2 diabetes compared to non diabetic subjects. We hypothesize that subjects with Type 2
diabetes make less insulin in response to GLP-1 compared to non diabetic subjects.
maintaining the function and health of the insulin producing beta cells. This hormone is
known to increase the production rate of new insulin as well as increase the release of
insulin into the blood. We will measure the rate of new insulin production in subjects with
Type 2 diabetes compared to non diabetic subjects. We hypothesize that subjects with Type 2
diabetes make less insulin in response to GLP-1 compared to non diabetic subjects.
Inclusion Criteria:
Type 2 Diabetes Non diabetic, weight, sex, age matched
Exclusion Criteria:
TZD, metformin, Exenatide, sitagliptin CHF, CAD CRF Anemia
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