A Pharmacokinetic Study to Assess Drug-drug Interaction Between Zanubrutinib and a Cocktail of Substrates in Healthy Subjects

Inclusion Criteria: All Groups

- Male subjects in good health as determined by past medical history, physical
examination, vital signs, ECG and laboratory tests at screening.

- Subjects must have a body mass index (BMI) between 18 and 32 kg/m2.

- Male subjects must agree to a highly effective method of birth control from screening
until at least 90 days after the last dose of study drug.

Exclusion Criteria:

- Subjects with a clinically relevant history or presence of any clinically significant
disease.

- History of stomach or intestinal surgery or resection that would potentially alter
absorption and/or excretion of orally administered drugs (uncomplicated appendectomy,
cholecystectomy, and hernia repair will be allowed).

- History of drug or alcohol abuse within 2 years prior to Check-In.

- Alcohol consumption of >21 units per week.

- A positive urine drug screen and/or positive alcohol breath test at Screening and/or
Check-in.

- A positive Hepatitis B surface antigen (HBsAg) or Hepatitis C test result and/or a
positive human immunodeficiency virus (HIV) at screening.

- Use of tobacco- or nicotine-containing products within 3 months prior to Check-In.

- History of blood donation of 56 days prior to Screening, plasma from 2 weeks prior to
Screening, or platelets from 6 weeks prior to Screening.