Assessment of tDCS-Induced Neuronal Responses in Multiple Sclerosis (MS) With Advanced MRI

Inclusion Criteria:

- Standardized SDMT Z-scores ≥3 standard deviations below mean

- Able to understand all study instructions and supply written consent

Exclusion Criteria:

- Extreme claustrophobia

- History of mental retardation, pervasive developmental disorder or other neurological
condition associated with cognitive impairment

- Primary psychiatric disorder that would influence ability to participate

- History of seizures or seizure disorder

- History of head trauma in the past year (e.g., head injury, brain surgery) or medical
device implanted in the head (such as Deep Brain Stimulator) or in the neck (such as a
Vagus Nerve Stimulator)

- Any skin disorder/sensitive skin (e.g., eczema, severe rashes), blisters, open wounds,
burn including sunburns, cuts or irritation, or other skin defects which compromise
the integrity of the skin at or near stimulation locations (where electrodes are
placed)

- Treatment for a communicable skin disorder currently or over the past 12 months

- History of uncontrolled or labile hypertension.

- Have any irremovable piercings, implantations or metallic-based tattoos

- History of clinically significant abnormalities on electrocardiogram (EKG)

- Pregnant or breastfeeding

- Current substance abuse disorder