Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

Inclusion Criteria:

- Patients has been clinically diagnosed with pulmonary hypertension (>25 mmHg) or
patient is a biopsy-proven non-rejecting cardiac transplant recipient

- Receiving partial or full care from pediatric cardiology team at Mott Children's
Hospital (may have a primary cardiologist elsewhere).

Exclusion Criteria:

- Girls and women who are pregnant or actively trying to become pregnant

- Patients with significant neurocognitive impairment that precludes their ability to
sign a consent form

- Patient has a contraindication to right-heart catheterization (RHC) examination, which
includes patients with hypoxia and those who have difficulty maintaining supine
position for the procedure.

- Patients with the following genetic syndromes:Trisomy 21 if unable to assent or
consent, Trisomy 18,Trisomy 13, Other genetic syndromes at the discretion of the
Primary Investigator

- Patients with unrepaired single ventricles (i.e., Pre-Fontan physiology)

- Patients who have heart failure and are deemed to be high risk to undergo tests that
require sedation/anesthesia.

- Patients who require IV sedation or general anesthesia for research only MRI

- Patients with a pacemaker/internal defibrillator will be excluded from MRI PORTION
ONLY