IV Insulin Protocol in Diabetes and Renal Transplantation
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Diabetes |
| Therapuetic Areas: | Endocrinology, Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/30/2013 |
| Start Date: | July 2007 |
| End Date: | June 2010 |
| Contact: | Shari A. Biggins, RN |
| Email: | biggins@musc.edu |
| Phone: | 843-792-9468 |
Intravenous Insulin Protocol in Diabetes and Renal Transplantation Study
Purpose: The purpose of this study is to provide tight blood sugar control using insulin
given through the veins at the time of kidney transplantation and up to 3 days after
surgery. After release from the hospital, the patient will control blood sugar with
subcutaneous insulin injections or pills. With this approach, outcomes should improve for
diabetic transplant patients such as longer life of the new kidney, fewer hospital
readmissions, decreased associated infections, and other advantages.
Hypothesis: It is hypothesized that intensive glycemic control will lead to better clinical
and biochemical outcomes and improved long-term graft survival.
Research Design: A randomized control trial comparing intensive intravenous insulin (IVI)
for use in the hospital followed by intensive subcutaneous (sc) insulin use for in-patient
and out-patient glycemic control will be conducted.
Inclusion Criteria:
- 18 years of age and greater,
- Diabetes diagnosis (Type 1 and Type 2, awaiting a living or cadaveric renal
transplant, renal transplant candidates admitted to MUSC medical center for a donor
kidney, FBG >100 mg/dL per admission screening labs, random BG >120mg/dL per
admission screening labs, and
- Willing and able to provide informed consent
Exclusion Criteria:
- History of an active GI bleed in the previous 3 mos,
- Scheduled to receive a simultaneous pancreas transplant,
- History of a functioning pancreatic transplant,
- Patient currently managed on an insulin pump,
- Unable or unwilling to provide informed consent, and
- Unable to commit to the study protocol including the outpatient follow-up phase of
care
We found this trial at
1
site
171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
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