COREG MR Versus TOPROL-XL On The Lipid Profile Of Normolipidemic Or Mildly Dyslipidemic Patients With Hypertension



Status:Completed
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 80
Updated:6/27/2018
Start Date:January 5, 2006
End Date:December 28, 2007

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A Randomized, Double-Blind, Multi-Center Study Comparing the Effects of Carvedilol Phosphate Modified Release Formulation (COREG- MR) With Metoprolol Succinate (TOPROL XL) on the Lipid Profile in Normolipidemic, or Mildly Dyslipidemic Hypertensive Patients

This study was designed to determine whether treatment with COREG MR is more effective at
maintaining a better lipid profile than treatment with TOPROL-XL for hypertension.


Inclusion Criteria:

- Documented history of hypertension

- Triglycerides of 120-400 mg/mL

- LDLc levels not requiring lipid lowering medication.

Exclusion Criteria:

- Has known contraindication to alpha- or beta-blocker therapy.

- Has taken any non-ocular beta-blockers within three months before screening.

- Has Type I or II diabetes.

- Taking lipid lowering medications.
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Calgary, Alberta
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