A Trial of Restrictive Versus Traditional Blood Transfusion Practices in Burn Patients

Status:	Active, not recruiting
Conditions:	Hospital
Therapuetic Areas:	Other
Healthy:	No
Age Range:	18 - Any
Updated:	1/12/2019
Start Date:	February 2010
End Date:	October 2019

A Randomized Clinical Trial of Restrictive vs. Traditional Blood Transfusion Practices in Burn Patients

The purpose of this study is to find out if burn injured patients do better receiving fewer
blood transfusions than what is traditionally given. We traditionally provide blood
transfusions to maintain a hemoglobin level, which is an indicator of the level of red blood
cells that carry oxygen in your body, to above 10 g/dl (g/dl stands for grams per deciliter
and is the standard measurement used to indicate the level of red blood cells in your blood).
However, a preliminary study indicated that maintaining the hemoglobin level to above 7-8
g/dl with less blood transfusion, as compared to a hemoglobin level of 10 g/dl and above,
would reduce the occurrence of blood infection, duration on the respirator and length of
hospital stay, yet would achieve similar survival in both groups.

Inclusion Criteria:

- >20% TBSA burn with anticipated operation need on admission as determined by attending
physician

- age >18 years

- Admission within 96 hours of injury

Exclusion Criteria:

- <18 years of age

- pregnancy

- inability or unwillingness to receive blood products

- history of chronic anemia (hemoglobin <9.0 g/dL one month prior to enrollment)

- preexisting need for hemodialysis

- brain death or imminent brain death

- non-survivable burn as determined by the attending burn surgeon

- angina or acute myocardial infarction

- preexisting hematologic disease

- Length of hospital stay anticipated to be < 2 weeks

- Transfusion administered at outside hospital before admit

We found this trial at

sites

University of Utah Intermountain School of Medicine

Salt Lake City, Utah 84132

from

Salt Lake City, UT