The Effect of Posterior Pericardiotomy on the Incidence of Atrial Fibrillation After Cardiac Surgery
Status: | Recruiting |
---|---|
Conditions: | Atrial Fibrillation |
Therapuetic Areas: | Cardiology / Vascular Diseases |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 10/25/2018 |
Start Date: | September 20, 2017 |
End Date: | September 2019 |
Contact: | Mario FL Gaudino, MD |
Email: | mfg9004@med.cornell.edu |
Phone: | 212-746-5460 |
The purpose of this study is to determine if preforming a posterior left pericardiotomy
prevents atrial fibrillation after cardiac surgery.
prevents atrial fibrillation after cardiac surgery.
Post-operative atrial fibrillation (POAF) is a common complication of cardiac surgery which
is observed in 30-40% of patients. POAF may cause stroke, systemic embolism or cardiac
failure and Its detection mandates for additional treatment with variable combinations of
drugs to control cardiac rate or rhythm, anticoagulation, and electrical cardioversion, with
their side effects and complications. As a result, POAF prolongs hospital stay and increases
the costs of hospitalization. Several strategies aimed at reducing the incidence of POAF have
been investigated, including beta-blockers, amiodarone, and statins, with unsatisfactory
results. Posterior left pericardiotomy has been associated with a reduction in the incidence
of POAF in a few studies. However, these studies are flawed by methodological limitations in
terms of sample size, inclusion/exclusion criteria, randomization procedure, and suboptimal
electrocardiographic monitoring strategies. Moreover, posterior left pericardiotomy requires
additional operative time and is associated with procedure-specific complications. As a
result, current evidence on posterior pericardiectomy failed to translate into changes in
clinical practice and the incidence of POAF remains high.
is observed in 30-40% of patients. POAF may cause stroke, systemic embolism or cardiac
failure and Its detection mandates for additional treatment with variable combinations of
drugs to control cardiac rate or rhythm, anticoagulation, and electrical cardioversion, with
their side effects and complications. As a result, POAF prolongs hospital stay and increases
the costs of hospitalization. Several strategies aimed at reducing the incidence of POAF have
been investigated, including beta-blockers, amiodarone, and statins, with unsatisfactory
results. Posterior left pericardiotomy has been associated with a reduction in the incidence
of POAF in a few studies. However, these studies are flawed by methodological limitations in
terms of sample size, inclusion/exclusion criteria, randomization procedure, and suboptimal
electrocardiographic monitoring strategies. Moreover, posterior left pericardiotomy requires
additional operative time and is associated with procedure-specific complications. As a
result, current evidence on posterior pericardiectomy failed to translate into changes in
clinical practice and the incidence of POAF remains high.
Inclusion Criteria:
- all consecutive patients admitted to the department of cardiothoracic surgery of the
NYPH-WCMC will be screened for enrollment.
Exclusion Criteria:
- preoperative non-sinus rhythm
- history of previous atrial arrhythmia of any type
- reoperations
- mitral or tricuspid valve disease
- surgery of the descending thoracic or thoracoabdominal aorta
- need for hypothermic circulatory arrest
- off pump operation
- urgent/emergent presentation
- disease of the left pleura or previous left thoracotomy
- chest deformity
We found this trial at
1
site
525 East 68th Street
New York, New York 10065
New York, New York 10065
Phone: 212-746-1815
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