Fontan Imaging Biomarkers (FIB) Study
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 3 - Any |
| Updated: | 6/27/2018 |
| Start Date: | September 2015 |
| End Date: | July 2022 |
| Contact: | Rahul H Rathod, MD |
| Email: | rahul.rathod@childrens.harvard.edu |
| Phone: | 617-355-4890 |
Cross-sectional Analysis of Non-invasive Measures of Ventricular Systolic and Diastolic Function and Biomarkers in the Fontan Circulation
The goal of the Fontan Imaging Biomarkers (FIB) study is to identify the associations of
blood and urine biomarkers to imaging parameters of ventricular mechanics.
blood and urine biomarkers to imaging parameters of ventricular mechanics.
This study has the following research questions:
1. What is the reproducibility of ventricular systolic function measurements (including
ventricular strain) in Fontan patients using echocardiography (Echo) and cardiac
magnetic resonance imaging (CMR)?
2. What is the reproducibility of ventricular diastolic function measurements (including
tissue Doppler and strain rate) in Fontan patients using Echo and CMR?
3. Is there a correlation between ventricular function measurements and circulating
biomarkers (including galectin-3 levels, NT-proBNP, ST2, and MELD-XI score)?
1. What is the reproducibility of ventricular systolic function measurements (including
ventricular strain) in Fontan patients using echocardiography (Echo) and cardiac
magnetic resonance imaging (CMR)?
2. What is the reproducibility of ventricular diastolic function measurements (including
tissue Doppler and strain rate) in Fontan patients using Echo and CMR?
3. Is there a correlation between ventricular function measurements and circulating
biomarkers (including galectin-3 levels, NT-proBNP, ST2, and MELD-XI score)?
Inclusion Criteria:
- All patients with Fontan circulation undergoing clinically indicated CMR at Boston
Children's Hospital will be considered for the study
Exclusion Criteria:
- Inadequate imaging quality to perform proposed analysis
- Patients <15 kg will be excluded to simplify compliance with BCH minimal risk research
blood draw volume guidelines (minimal risk is defined as < 5% total blood volume)
We found this trial at
1
site
300 Longwood Ave
Boston, Massachusetts 02115
Boston, Massachusetts 02115
(617) 355-6000
Phone: 617-355-4890
Boston Children's Hospital Boston Children's Hospital is a 395-bed comprehensive center for pediatric health care....
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