Cardiac Rehab for Advanced Heart Failure-LVAD Candidates
| Status: | Withdrawn |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/27/2018 |
| Start Date: | April 2017 |
| End Date: | February 2018 |
A Prospective Trial to Evaluate the Utility of Focused Frailty Interventions on Patients Undergoing Evaluation for Left Ventricular Assist Device (LVAD) Placement
This study is a pilot study evaluating the feasibility and early efficacy of cardiac
rehabilitation to improve frailty and symptoms in patients with advanced heart failure (NYHA
class III-IV), who are being considered for LVAD therapy.
rehabilitation to improve frailty and symptoms in patients with advanced heart failure (NYHA
class III-IV), who are being considered for LVAD therapy.
Frailty in patients with advanced heart failure is not thoroughly described, but in those
studies that assessed frailty, it was a common phenomenon. Furthermore, some data suggest an
association between pre-LVAD implant frailty and post-implant complications and survival.
Interventions for frailty have been utilized in various populations, including the elderly
frail and the frail from cardiovascular causes. These interventions target physical
strengthening and endurance and have been shown on occasion to improve functional outcomes.
The current study, a pilot study, seeks to assess frailty in a prospective cohort of patients
being evaluated in Heart Failure Clinic for consideration of LVAD implantation due to NYHA
class III-IV dyspnea and enroll these patients in a six-week focused cardiac rehabilitation
protocol aimed at improving frailty and functional independence. The primary endpoint of the
study is improvement in frailty markers at the end (gait speed, handgrip strength), and
secondary endpoints include improvement in the indices of quality of life and symptomatology
via validated questionnaires.
studies that assessed frailty, it was a common phenomenon. Furthermore, some data suggest an
association between pre-LVAD implant frailty and post-implant complications and survival.
Interventions for frailty have been utilized in various populations, including the elderly
frail and the frail from cardiovascular causes. These interventions target physical
strengthening and endurance and have been shown on occasion to improve functional outcomes.
The current study, a pilot study, seeks to assess frailty in a prospective cohort of patients
being evaluated in Heart Failure Clinic for consideration of LVAD implantation due to NYHA
class III-IV dyspnea and enroll these patients in a six-week focused cardiac rehabilitation
protocol aimed at improving frailty and functional independence. The primary endpoint of the
study is improvement in frailty markers at the end (gait speed, handgrip strength), and
secondary endpoints include improvement in the indices of quality of life and symptomatology
via validated questionnaires.
Inclusion Criteria:
- Candidate for a Left Ventricular Assist Device (LVAD)
- Advanced Heart Failure as determined by New York Heart Association classification III
or IV
Exclusion Criteria:
- Unable to perform physical activities required by protocol due to anatomic or
musculoskeletal comorbidities
- Physical activity is contraindicated
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