Weight-based Flow Rates for Children With Bronchiolitis on High-Flow Nasal Cannula: A Pilot Randomized Control Trial
| Status: | Recruiting |
|---|---|
| Conditions: | Bronchitis |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any - 2 |
| Updated: | 6/27/2018 |
| Start Date: | May 1, 2018 |
| End Date: | April 30, 2019 |
| Contact: | Alla L Smith, MD |
| Email: | alla.smith@childrens.harvard.edu |
| Phone: | 443-744-1610 |
This is a pilot study comparing a weight-based high-flow nasal cannula (HFNC) protocol with
the current standard HFNC protocol for children <2yo admitted to South Shore Hospital with
bronchiolitis. We currently use a flat limit of 8 liters of HFNC to support work of breathing
and hypoxia in these patients. We will compare that to a weight-based protocol, which will
provide 2L/kg/min of flow (flows generally between 6 and 20L/minute) to this patient
population. The goal of this pilot study is to assess the feasibility of our study design. We
will evaluate the functionality of a new weight-based flow protocol. We will also evaluate
the functionality of a new bronchiolitis scoring tool, the Bronchiolitis Assessment Severity
Score (BASS), and it's ability to guide care through the new protocol. We are also testing
the feasibility of recruitment, randomization and retention. We are ultimately interested in
whether a weight-based flow protocol reduces need for escalation to ICU-level care for
children with moderate-severe bronchiolitis on HFNC.
the current standard HFNC protocol for children <2yo admitted to South Shore Hospital with
bronchiolitis. We currently use a flat limit of 8 liters of HFNC to support work of breathing
and hypoxia in these patients. We will compare that to a weight-based protocol, which will
provide 2L/kg/min of flow (flows generally between 6 and 20L/minute) to this patient
population. The goal of this pilot study is to assess the feasibility of our study design. We
will evaluate the functionality of a new weight-based flow protocol. We will also evaluate
the functionality of a new bronchiolitis scoring tool, the Bronchiolitis Assessment Severity
Score (BASS), and it's ability to guide care through the new protocol. We are also testing
the feasibility of recruitment, randomization and retention. We are ultimately interested in
whether a weight-based flow protocol reduces need for escalation to ICU-level care for
children with moderate-severe bronchiolitis on HFNC.
Inclusion Criteria:
- admission to inpatient pediatrics
- clinical diagnosis of bronchiolitis
- BASS score of moderate or severe
Exclusion Criteria:
- non-english speakers
- patients with urgent need for CPAP, BIPAP or intubation
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