Virtual Reality in Reducing Pain and Anxiety in Cancer Participants Undergoing Painful Procedures

PRIMARY OBJECTIVES:

I. To determine the feasibility of VR in patients undergoing procedural intervention.

SECONDARY OBJECTIVES:

I. To estimate differences between the two arms in terms of pain and anxiety. II. To document
any adverse events that could possibly be attributed to the VR intervention.

EXPLORATORY OBJECTIVES:

I. Explore the use of biomarkers as a tool to reflect the impact of intervention.

OUTLINE: Participants are randomized to 1 of 2 arms.

ARM I: Participants undergo VR intervention peri-procedure (bone marrow biopsy or lumbar
puncture) lasting until completion of the procedure.

ARM II: Participants receive standard of care during procedure (bone marrow biopsy or lumbar
puncture).

Inclusion Criteria:

- Patient has been diagnosed with any cancer

- Patient is currently hospitalized and receiving treatment for a primary or secondary
cancer at University of Southern California (USC) Norris Comprehensive Cancer Center
and Hospital

- Patient is undergoing a bone marrow biopsy or lumbar puncture

Exclusion Criteria:

- Inability to sign informed assent and/or consent

- Patient with an underlying diagnosis of epilepsy, dementia, Parkinson?s disease,
primary central nervous system malignancy, brain metastasis, underlying inflammatory
or infectious central nervous system disorder, inner ear infection, history of
vertigo, baseline visual or hearing impairment, macular degeneration, untreated
glaucoma, implantable medical devices or any medical condition that investigator deems
contraindicated

- Patient with an underlying chronic pain disorder, anxiety disorder, depressive
disorder, or other psychiatric illness unspecified

- Patient with active Clostridium difficile infection

- Patient on any acute (within last < 24 hour [hr]) or chronic pain medication (opioid,
nonsteroidal anti-inflammatory drug [NSAID], steroid)

- Patient on chronic steroids > 10 mg prednisone equivalent daily or other
immunosuppressant > 1 week

- Patient who is post bone marrow transplant

- Patient with a body mass index (BMI) > 35