Implementation of Smoking Cessation Within NCI NCORP Community Sites

We utilize an effectiveness-implementation hybrid design, employing a cluster, randomized
control trial of community-based NCORP sites to study the effectiveness of a multi-faceted
intervention to improve smoking cessation among lung cancer screening patients, as well as
dissemination and implementation (D&I) science to optimize and accelerate translation of
findings into clinical practice. We will: (1) Evaluate a multi-faceted training program to
improve short-term smoking cessation rates (1-week post-visit) and sustained abstinence (6
months) among 1,114 enrolled smokers (557 in each trial arm) who present for LDCT lung cancer
screening in community-based lung cancer screening practices; (2) Characterize the adoption
and adaptation of the evidence-based tobacco cessation strategies in 26 community-based LDCT
lung cancer screening programs; and (3) Develop and evaluate an implementation toolkit for
integrating evidence-based tobacco cessation strategies in community-based LDCT lung cancer
screening programs. Qualitative data will be collected from key informants at participating
screening programs during and after intervention implementation. Quantitative survey data
(baseline, <14 days, 3 months, and 6 months) and saliva specimens (6 months only) will be
collected from smoking patients receiving screening within these programs.

Inclusion Criteria:

- Agrees to have NCORP research personnel serve as the study liaison and another person
to serve as the cessation program champion.

- Agrees to participate in all aspects of the intervention, randomization, and
evaluation.

- Agrees to participate in a confidential 1-on-1 semi-structured interview with the
research team.

- Agrees to have the interview taped, transcribed and qualitatively analyzed.

- Age ≥18 years

- Potential participants will be screened using the following question: "Do you smoke
cigarettes every day, some days, or not at all?" (BRFSS). A current smoker is anyone
responds "every day" or "some days".

Exclusion Criteria:

- Current use (previous 30 days) of a tobacco dependence treatment including bupropion,
varenicline, and nicotine replacement

- Individuals who use e-cigarettes and who are not smoking cigarettes. Dual users (those
who use both e-cigarettes and cigarettes) will still be included in the trial.

- The presence of a physical or cognitive impairment that would prevent a person from
engaging in survey research (such as blindness, deafness, or dementia)

- Non-English speaking participants