The Arthritis, Diet, and Activity Promotion Trial
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 60 - Any |
| Updated: | 8/3/2018 |
| Start Date: | November 1997 |
| End Date: | December 2000 |
The primary purpose of this study was to determine the effect of dietary weight-loss,
exercise training, or a combination of both on physical function in overweight and obese
adults with knee osteoarthritis (OA). In secondary analyses, the effect of weight-loss and/or
exercise on OA progression, self-reported pain and inflammation were examined. In post-trial
analyses, the effect of dietary weight-loss on total mortality was determined.
exercise training, or a combination of both on physical function in overweight and obese
adults with knee osteoarthritis (OA). In secondary analyses, the effect of weight-loss and/or
exercise on OA progression, self-reported pain and inflammation were examined. In post-trial
analyses, the effect of dietary weight-loss on total mortality was determined.
Inclusion Criteria:
- Age ≥ 60 years.
- BMI ≥ 28 kg/m2.
- Knee pain on most days of the month.
- Sedentary lifestyle pattern (<20 min exercise per week for last 6 months)
- Self-reported difficulty with at least one of the following: walking 1/4 mile,
climbing stairs, kneeling, bending, stooping, shopping, lifting, self-care.
- Radiographic evidence of grade 1-3 knee osteoarthritis.
Exclusion Criteria:
- Serious medical condition that precludes safe participation in exercise such as heart
disease (angina, congestive heart failure), severe hypertension, COPD, renal or liver
disease, insulin-dependent diabetes.
- Mini-mental state exam score <24.
- Inability to walks without a cane.
- Reported alcohol consumption >14 drinks/week.
- Inability to complete protocol.
- ST segment depression.
- Participation in another research study.
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