Effect of an EAA/Whey Composition on Protein Metabolism
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 8/17/2018 |
| Start Date: | June 20, 2018 |
| End Date: | May 1, 2020 |
Effect of an Essential Amino Acid/Protein Composition on Protein Metabolism
Sarcopenia, a progressive loss of muscle mass, strength and function, is an inevitable
natural process of aging. While it may be impossible to completely reverse the progress of
sarcopenia, it is well established that intake of dietary protein through essential amino
acids (EAAs) and whey protein increases anabolic response. The current study will test if a
specially formulated mixture of EAAs and whey protein can maximally stimulate anabolic
responses at the levels of whole body and muscle compared to whey protein alone.
natural process of aging. While it may be impossible to completely reverse the progress of
sarcopenia, it is well established that intake of dietary protein through essential amino
acids (EAAs) and whey protein increases anabolic response. The current study will test if a
specially formulated mixture of EAAs and whey protein can maximally stimulate anabolic
responses at the levels of whole body and muscle compared to whey protein alone.
The product composition is protected by intellectual property. It contains a combination of
ingredients designed to stimulate anabolic responses at whole body and muscle and to
ultimately induce long-term improvements in muscle function and size. EAAs are the only
dietary macronutrients that are required for survival. They are "essential" because the body
cannot produce them. There are 9 dietary EAAs while there are 11 dietary non-essential amino
acids that are not required in the diet because they can be produced in the body. The
composition is based on a blend of 8 of the 9 EAAs. In addition to being the "active"
components of dietary protein, EAAs also have the advantage over intact protein including
whey protein because free EAAs are absorbed from the intestine more quickly and more
completely than amino acids contained in protein, which requires digestion before absorption
indicating that intact protein is relatively slowly absorbed. Therefore, the combination of
free EAAs and intact protein give not only an immediate response (from the free EAAs) but
also a prolonged response (from the intact protein) over time by the slower digestion. The
idea of combining a specific formulation of EAAs with an intact protein to obtain both an
immediate as well as a more sustained response in protein anabolism is novel. Investigators
propose that consumption of the EAA/protein composition will stimulate the net protein
balance at the whole body level in a dose-dependent manner. The investigators further propose
that the magnitude of increase in the net protein balance will be greater than induced by the
consumption of the same amount of whey protein isolate.
ingredients designed to stimulate anabolic responses at whole body and muscle and to
ultimately induce long-term improvements in muscle function and size. EAAs are the only
dietary macronutrients that are required for survival. They are "essential" because the body
cannot produce them. There are 9 dietary EAAs while there are 11 dietary non-essential amino
acids that are not required in the diet because they can be produced in the body. The
composition is based on a blend of 8 of the 9 EAAs. In addition to being the "active"
components of dietary protein, EAAs also have the advantage over intact protein including
whey protein because free EAAs are absorbed from the intestine more quickly and more
completely than amino acids contained in protein, which requires digestion before absorption
indicating that intact protein is relatively slowly absorbed. Therefore, the combination of
free EAAs and intact protein give not only an immediate response (from the free EAAs) but
also a prolonged response (from the intact protein) over time by the slower digestion. The
idea of combining a specific formulation of EAAs with an intact protein to obtain both an
immediate as well as a more sustained response in protein anabolism is novel. Investigators
propose that consumption of the EAA/protein composition will stimulate the net protein
balance at the whole body level in a dose-dependent manner. The investigators further propose
that the magnitude of increase in the net protein balance will be greater than induced by the
consumption of the same amount of whey protein isolate.
Inclusion Criteria:
- BMI between 20 and 30 kg/m^2
Exclusion Criteria:
- Current diagnosis of diabetes
- History of malignancy in the 6 months prior to enrollment
- Weight reduction surgery
- Chronic inflammatory (Lupus, HIV/AIDS)
- Currently pregnant females
- Unable to eat dairy protein
- Unable to stop eating protein or Amino Acid (AA) supplements during the participation
- Regular resistance training (> once per week)
- Concomitant use of corticosteroids (ingestion, injection or transdermal)
- Subjects who cannot safely stop using aspirin for 7 days prior to muscle biopsies
- Hemoglobin less than 9.5 g/dL, and platelets less than 150,000 at the screening visit
- Any other disease or condition placing the subject at increased risk of harm if they
were to participate, at the discretion of the study physician
We found this trial at
1
site
529 West Markham Street
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
(501) 686-7000
Phone: 501-526-5711
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
Click here to add this to my saved trials
