A Study to Assess if Mirikizumab is Effective and Safe Compared to Secukinumab and Placebo in Moderate to Severe Plaque Psoriasis (OASIS-2)



Status:Recruiting
Conditions:Psoriasis
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:18 - Any
Updated:4/5/2019
Start Date:June 26, 2018
End Date:December 11, 2020
Contact:There may be multiple sites in this clinical trial. 1-877-CTLILLY
Email:ClinicalTrials.gov@lilly.com
Phone:1-317-615-4559

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Trial Summary
Trial Overview
Inclusion Criteria

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Efficacy and Safety of Mirikizumab to Secukinumab and Placebo in Patients With Moderate-to-Severe Plaque Psoriasis OASIS-2

The reason for this study is to see how effective and safe mirikizumab is compared to
secukinumab and placebo for moderate to severe plaque psoriasis.


Inclusion Criteria:

- Participant must have chronic plaque psoriasis for at least 6 months.

Exclusion Criteria:

- Participant must not be breastfeeding or nursing woman.

- Participant must not have had serious, opportunistic, or chronic/recurring infection
within 3 months.

- Participant must not have received a Bacillus Calmette-Guerin (BCG) vaccination within
12 months or received live vaccine(s) (including attenuated live vaccines) within 12
weeks of baseline or intend to receive either during the study.

- Participant must not have any other skin conditions (excluding psoriasis).

- Participant must not have previous exposure to Cosentyx and any other biologic therapy
targeting IL-17 (including Taltz).

- Participant must not have received anti-tumor necrosis factor (TNF) biologics within 8
weeks.

- Participant must not have previous exposure to any biologic therapy targeting IL-23
(including Stelara).
We found this trial at
48
sites
PMG Research of Wilmington
1907 Tradd Ct
Wilmington, North Carolina 28401
(910) 799-5500
Principal Investigator: James E Appel
Phone: 910-799-5500
PMG Research of Wilmington PMG Research of Wilmington has two offices situated in a 1...
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University of Alabama at Birmingham
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Boni Elizabeth Elewski
Phone: 2055029960
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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Psoriasis Treatment Center of Central New Jersey
59 One Mile Road
East Windsor, New Jersey 08520
609-443-4500
Principal Investigator: Jerry Bagel
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East Windsor, NJ
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Oregon Health and Science University
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Principal Investigator: Alex Ortega Loayza
Phone: 503-494-4770
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Portland, OR
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ORA Inc
Andover, Massachusetts 01810
Principal Investigator: Jeffrey M Sobell
Phone: 978-685-8900
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Andover, MA
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Austin Institute for Clinical Research Inc.
Austin, Texas 78660
Principal Investigator: Aron Jeffrey Gewirtzman
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Austin, TX
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Bakersfield Dermatology and Skin Cancer Medical Group
Bakersfield, California 99309
Principal Investigator: Jeffrey James Crowley
Phone: 6613273756
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Bakersfield, CA
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Louisiana Dermatology Associates
Baton Rouge, Louisiana 70806
Principal Investigator: Ira Hughes Thorla
Phone: 2259275663
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Baton Rouge, LA
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David Stoll, MD
Beverly Hills, California 90212
Principal Investigator: David M Stoll
Phone: 310-273-6033
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Bexley Dermatology Research
Bexley, Ohio 43209
Principal Investigator: Matthew Zirwas
Phone: 614-725-1716
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Bexley, OH
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Treasure Valley Dermatology
6051 North Eagle Road
Boise, Idaho 83713
Principal Investigator: Ryan Harris
Phone: 208-467-3006
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Boise, ID
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CEDIC-Centro de Investigaciones Clinicas
Caba, Buenos Aires
Principal Investigator: Nora Noemi Kogan
Phone: 541148238701
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PMG Research of Cary
Cary, North Carolina 27518
Principal Investigator: Catherine Hren
Phone: 919-342-3447
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Cary, NC
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University of North Carolina Dermatology and skin Cancer Cen
410 Market Street
Chapel Hill, North Carolina 27516
Principal Investigator: Aida Lugo-Somolinos
Phone: 984-974-3672
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University Hospitals of Cleveland Medical Center
Cleveland, Ohio 44012
Principal Investigator: Neil J Korman
Phone: 216-844-3178
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Modern Research Associates
Dallas, Texas 75231
Principal Investigator: Jennifer A Cather
Phone: 214-361-2008
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University Dermatology
Darien, Illinois 60561
Principal Investigator: Vassilios A Dimitropoulos
Phone: 630-920-1900
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Darien, IL
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California Dermatology and Clinical Research Institute
Encinitas, California 92024
Principal Investigator: Stacy R. Smith
Phone: 760-203-3839
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Wright State Physicians Dermatology
725 University Boulevard
Fairborn, Ohio 45324
Principal Investigator: Jeffrey Travers
Phone: 937-775-2463
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Tien Q. Nguyen, MD inc. DBA First OC Dermatology
17271 Brookhurst Street
Fountain Valley, California 92708
Principal Investigator: Vivian Laquer
Phone: 714-531-2966
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Dawes Fretzin Clinical Research
Indianapolis, Indiana 46256
Principal Investigator: Scott A Fretzin
Phone: 317-621-7731
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Indianapolis, IN
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Clinical Partners, LLC
Johnston, Rhode Island 02919
Principal Investigator: Ellen H Frankel
Phone: 401-454-3800
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Keck School of Medicine - University of Southern California
Los Angeles, California 90033
Principal Investigator: Stefani Takahashi
Phone: 323-865-3641
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Los Angeles, CA
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Dermatology Specialist
Louisville, Kentucky 40202
Principal Investigator: Cindy E Owen
Phone: 502-585-9059
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Louisville, KY
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Dermatologic Surgery Specialists, Inc.
Macon, Georgia 31217
Principal Investigator: David J Cohen
Phone: 478-742-2180
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Macon, GA
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Mount Sinai School of Medicine Dermatology Clinical Trials
New York, New York 10029
Principal Investigator: Mark G. Lebwohl
Phone: 212-241-3288
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New York, NY
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MedaPhase, Inc.
Newnan, Georgia 30263
Principal Investigator: Mark R Ling
Phone: 770-252-6900
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Newnan, GA
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Dermatology Clinical Trials
Newport Beach, California 92660
Principal Investigator: Navid Nami
Phone: 949-720-1170
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Virginia Clinical Research, Inc.
Norfolk, Virginia 23507
Principal Investigator: David M Pariser
Phone: 757-622-6315
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Norfolk, VA
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Park Avenue Dermatology
Orange Park, Florida 32073
Principal Investigator: George Schmieder
Phone: 904-458-0411
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Orange Park, FL
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Owensboro Dermatology Associates
Owensboro, Kentucky 42303
Principal Investigator: Artis P Truett
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Austin Institute for Clinical Research, Inc.
Pflugerville, Texas 78660
Principal Investigator: Edward Lain
Phone: 512-279-2545
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The Indiana Clinical Trials Center, PC
Plainfield, Indiana 46168
Principal Investigator: Scott T Guenthner
Phone: 317-837-6082
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Oregon Dermatology & Research Center
Portland, Oregon 97210
Principal Investigator: Phoebe Rich
Phone: 503-226-3376
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Dermatology and Skin Cancer Specialists
Rockville, Maryland 20850
Principal Investigator: Benjamin N. Lockshin
Phone: 301-355-3183
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Rockville, MD
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Lawrence J. Green, MD, LLC
Rockville, Maryland 20850
Principal Investigator: Lawrence Green
Phone: 301-610-0663
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Arlington Dermatology
5301 Keystone Court
Rolling Meadows, Illinois 60008
Principal Investigator: Michael Bukhalo
Phone: 847-392-5440
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Rolling Meadows, IL
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Central Dermatology
Saint Louis, Missouri 63117
Principal Investigator: Craig L Leonardi
Phone: 314-721-5565
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Saint Louis, MO
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Texas Dermatology and Laser Specialists
San Antonio, Texas 78218
Principal Investigator: John C. Browning
Phone: 210-829-5180
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Stephen L Miller, MD, PA
San Antonio, Texas 78249
Principal Investigator: William Cragun
Phone: 210-614-2662
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San Luis Dermatology & Laser Clinic, Inc.
15 Santa Rosa Street
San Luis Obispo, California 93405
Principal Investigator: Michael Heffernan
Phone: 805-541-2650
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Clinical Science Institute
Santa Monica, California 90404
Principal Investigator: Paul S Yamauchi
Phone: 310-828-8887
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Santa Monica, CA
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Meridian Clinical Research, LLC
Savannah, Georgia 31406
Principal Investigator: Corinne Howington
Phone: 912-443-4253
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Savannah, GA
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Investigate MD
Scottsdale, Arizona 85255
Principal Investigator: Brenda LaTowsky
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DBA Dermatology Associates
Seattle, Washington 98101
Principal Investigator: Peter J Jenkin
Phone: 206-315-0377
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South Bend Clinic
211 North Eddy St.
South Bend, Indiana 46617
574-234-8161
Principal Investigator: Holly Hake Harris
Phone: 574-204-6432
South Bend Clinic The South Bend Clinic employs a staff of 610 at its five...
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Center for Clinical Studies
Webster, Texas 77598
Principal Investigator: Patricia C. Lee
Phone: 281-333-2288
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Jordan Valley Dermatology Center
West Jordan, Utah 84088
Principal Investigator: Douglass W Forsha
Phone: 801-316-0266
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