A Study to Assess if Mirikizumab is Effective and Safe Compared to Secukinumab and Placebo in Moderate to Severe Plaque Psoriasis (OASIS-2)



Status:Recruiting
Conditions:Psoriasis
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:18 - Any
Updated:4/5/2019
Start Date:June 26, 2018
End Date:December 11, 2020
Contact:There may be multiple sites in this clinical trial. 1-877-CTLILLY
Email:ClinicalTrials.gov@lilly.com
Phone:1-317-615-4559

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Efficacy and Safety of Mirikizumab to Secukinumab and Placebo in Patients With Moderate-to-Severe Plaque Psoriasis OASIS-2

The reason for this study is to see how effective and safe mirikizumab is compared to
secukinumab and placebo for moderate to severe plaque psoriasis.


Inclusion Criteria:

- Participant must have chronic plaque psoriasis for at least 6 months.

Exclusion Criteria:

- Participant must not be breastfeeding or nursing woman.

- Participant must not have had serious, opportunistic, or chronic/recurring infection
within 3 months.

- Participant must not have received a Bacillus Calmette-Guerin (BCG) vaccination within
12 months or received live vaccine(s) (including attenuated live vaccines) within 12
weeks of baseline or intend to receive either during the study.

- Participant must not have any other skin conditions (excluding psoriasis).

- Participant must not have previous exposure to Cosentyx and any other biologic therapy
targeting IL-17 (including Taltz).

- Participant must not have received anti-tumor necrosis factor (TNF) biologics within 8
weeks.

- Participant must not have previous exposure to any biologic therapy targeting IL-23
(including Stelara).
We found this trial at
48
sites
The Indiana Clinical Trials Center, PC
Plainfield, Indiana 46168
Principal Investigator: Scott T Guenthner
Phone: 317-837-6082
?
mi
from
Plainfield, IN
Click here to add this to my saved trials
University of Alabama at Birmingham
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Boni Elizabeth Elewski
Phone: 2055029960
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Psoriasis Treatment Center of Central New Jersey
59 One Mile Road
East Windsor, New Jersey 08520
609-443-4500
Principal Investigator: Jerry Bagel
?
mi
from
East Windsor, NJ
Click here to add this to my saved trials
Oregon Health and Science University
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Principal Investigator: Alex Ortega Loayza
Phone: 503-494-4770
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
?
mi
from
Portland, OR
Click here to add this to my saved trials
ORA Inc
Andover, Massachusetts 01810
Principal Investigator: Jeffrey M Sobell
Phone: 978-685-8900
?
mi
from
Andover, MA
Click here to add this to my saved trials
Austin Institute for Clinical Research Inc.
Austin, Texas 78660
Principal Investigator: Aron Jeffrey Gewirtzman
?
mi
from
Austin, TX
Click here to add this to my saved trials
Bakersfield Dermatology and Skin Cancer Medical Group
Bakersfield, California 99309
Principal Investigator: Jeffrey James Crowley
Phone: 6613273756
?
mi
from
Bakersfield, CA
Click here to add this to my saved trials
Louisiana Dermatology Associates
Baton Rouge, Louisiana 70806
Principal Investigator: Ira Hughes Thorla
Phone: 2259275663
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
David Stoll, MD
Beverly Hills, California 90212
Principal Investigator: David M Stoll
Phone: 310-273-6033
?
mi
from
Beverly Hills, CA
Click here to add this to my saved trials
Bexley Dermatology Research
Bexley, Ohio 43209
Principal Investigator: Matthew Zirwas
Phone: 614-725-1716
?
mi
from
Bexley, OH
Click here to add this to my saved trials
Treasure Valley Dermatology
6051 North Eagle Road
Boise, Idaho 83713
Principal Investigator: Ryan Harris
Phone: 208-467-3006
?
mi
from
Boise, ID
Click here to add this to my saved trials
CEDIC-Centro de Investigaciones Clinicas
Caba, Buenos Aires
Principal Investigator: Nora Noemi Kogan
Phone: 541148238701
?
mi
from
Caba,
Click here to add this to my saved trials
PMG Research of Cary
Cary, North Carolina 27518
Principal Investigator: Catherine Hren
Phone: 919-342-3447
?
mi
from
Cary, NC
Click here to add this to my saved trials
University of North Carolina Dermatology and skin Cancer Cen
410 Market Street
Chapel Hill, North Carolina 27516
Principal Investigator: Aida Lugo-Somolinos
Phone: 984-974-3672
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
University Hospitals of Cleveland Medical Center
Cleveland, Ohio 44012
Principal Investigator: Neil J Korman
Phone: 216-844-3178
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Modern Research Associates
Dallas, Texas 75231
Principal Investigator: Jennifer A Cather
Phone: 214-361-2008
?
mi
from
Dallas, TX
Click here to add this to my saved trials
University Dermatology
Darien, Illinois 60561
Principal Investigator: Vassilios A Dimitropoulos
Phone: 630-920-1900
?
mi
from
Darien, IL
Click here to add this to my saved trials
California Dermatology and Clinical Research Institute
Encinitas, California 92024
Principal Investigator: Stacy R. Smith
Phone: 760-203-3839
?
mi
from
Encinitas, CA
Click here to add this to my saved trials
Wright State Physicians Dermatology
725 University Boulevard
Fairborn, Ohio 45324
Principal Investigator: Jeffrey Travers
Phone: 937-775-2463
?
mi
from
Fairborn, OH
Click here to add this to my saved trials
Tien Q. Nguyen, MD inc. DBA First OC Dermatology
17271 Brookhurst Street
Fountain Valley, California 92708
Principal Investigator: Vivian Laquer
Phone: 714-531-2966
?
mi
from
Fountain Valley, CA
Click here to add this to my saved trials
Dawes Fretzin Clinical Research
Indianapolis, Indiana 46256
Principal Investigator: Scott A Fretzin
Phone: 317-621-7731
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Clinical Partners, LLC
Johnston, Rhode Island 02919
Principal Investigator: Ellen H Frankel
Phone: 401-454-3800
?
mi
from
Johnston, RI
Click here to add this to my saved trials
Keck School of Medicine - University of Southern California
Los Angeles, California 90033
Principal Investigator: Stefani Takahashi
Phone: 323-865-3641
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Dermatology Specialist
Louisville, Kentucky 40202
Principal Investigator: Cindy E Owen
Phone: 502-585-9059
?
mi
from
Louisville, KY
Click here to add this to my saved trials
Dermatologic Surgery Specialists, Inc.
Macon, Georgia 31217
Principal Investigator: David J Cohen
Phone: 478-742-2180
?
mi
from
Macon, GA
Click here to add this to my saved trials
Mount Sinai School of Medicine Dermatology Clinical Trials
New York, New York 10029
Principal Investigator: Mark G. Lebwohl
Phone: 212-241-3288
?
mi
from
New York, NY
Click here to add this to my saved trials
MedaPhase, Inc.
Newnan, Georgia 30263
Principal Investigator: Mark R Ling
Phone: 770-252-6900
?
mi
from
Newnan, GA
Click here to add this to my saved trials
Dermatology Clinical Trials
Newport Beach, California 92660
Principal Investigator: Navid Nami
Phone: 949-720-1170
?
mi
from
Newport Beach, CA
Click here to add this to my saved trials
Virginia Clinical Research, Inc.
Norfolk, Virginia 23507
Principal Investigator: David M Pariser
Phone: 757-622-6315
?
mi
from
Norfolk, VA
Click here to add this to my saved trials
Park Avenue Dermatology
Orange Park, Florida 32073
Principal Investigator: George Schmieder
Phone: 904-458-0411
?
mi
from
Orange Park, FL
Click here to add this to my saved trials
Owensboro Dermatology Associates
Owensboro, Kentucky 42303
Principal Investigator: Artis P Truett
?
mi
from
Owensboro, KY
Click here to add this to my saved trials
Austin Institute for Clinical Research, Inc.
Pflugerville, Texas 78660
Principal Investigator: Edward Lain
Phone: 512-279-2545
?
mi
from
Pflugerville, TX
Click here to add this to my saved trials
Oregon Dermatology & Research Center
Portland, Oregon 97210
Principal Investigator: Phoebe Rich
Phone: 503-226-3376
?
mi
from
Portland, OR
Click here to add this to my saved trials
Dermatology and Skin Cancer Specialists
Rockville, Maryland 20850
Principal Investigator: Benjamin N. Lockshin
Phone: 301-355-3183
?
mi
from
Rockville, MD
Click here to add this to my saved trials
Lawrence J. Green, MD, LLC
Rockville, Maryland 20850
Principal Investigator: Lawrence Green
Phone: 301-610-0663
?
mi
from
Rockville, MD
Click here to add this to my saved trials
Arlington Dermatology
5301 Keystone Court
Rolling Meadows, Illinois 60008
Principal Investigator: Michael Bukhalo
Phone: 847-392-5440
?
mi
from
Rolling Meadows, IL
Click here to add this to my saved trials
Central Dermatology
Saint Louis, Missouri 63117
Principal Investigator: Craig L Leonardi
Phone: 314-721-5565
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Texas Dermatology and Laser Specialists
San Antonio, Texas 78218
Principal Investigator: John C. Browning
Phone: 210-829-5180
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
Stephen L Miller, MD, PA
San Antonio, Texas 78249
Principal Investigator: William Cragun
Phone: 210-614-2662
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
San Luis Dermatology & Laser Clinic, Inc.
15 Santa Rosa Street
San Luis Obispo, California 93405
Principal Investigator: Michael Heffernan
Phone: 805-541-2650
?
mi
from
San Luis Obispo, CA
Click here to add this to my saved trials
Clinical Science Institute
Santa Monica, California 90404
Principal Investigator: Paul S Yamauchi
Phone: 310-828-8887
?
mi
from
Santa Monica, CA
Click here to add this to my saved trials
Meridian Clinical Research, LLC
Savannah, Georgia 31406
Principal Investigator: Corinne Howington
Phone: 912-443-4253
?
mi
from
Savannah, GA
Click here to add this to my saved trials
Investigate MD
Scottsdale, Arizona 85255
Principal Investigator: Brenda LaTowsky
?
mi
from
Scottsdale, AZ
Click here to add this to my saved trials
DBA Dermatology Associates
Seattle, Washington 98101
Principal Investigator: Peter J Jenkin
Phone: 206-315-0377
?
mi
from
Seattle, WA
Click here to add this to my saved trials
South Bend Clinic
211 North Eddy St.
South Bend, Indiana 46617
574-234-8161
Principal Investigator: Holly Hake Harris
Phone: 574-204-6432
South Bend Clinic The South Bend Clinic employs a staff of 610 at its five...
?
mi
from
South Bend, IN
Click here to add this to my saved trials
Center for Clinical Studies
Webster, Texas 77598
Principal Investigator: Patricia C. Lee
Phone: 281-333-2288
?
mi
from
Webster, TX
Click here to add this to my saved trials
Jordan Valley Dermatology Center
West Jordan, Utah 84088
Principal Investigator: Douglass W Forsha
Phone: 801-316-0266
?
mi
from
West Jordan, UT
Click here to add this to my saved trials
PMG Research of Wilmington
1907 Tradd Ct
Wilmington, North Carolina 28401
(910) 799-5500
Principal Investigator: James E Appel
Phone: 910-799-5500
PMG Research of Wilmington PMG Research of Wilmington has two offices situated in a 1...
?
mi
from
Wilmington, NC
Click here to add this to my saved trials