Lipids, Inflammation, and CV Risk in RA
| Status: | Recruiting |
|---|---|
| Conditions: | Arthritis, Peripheral Vascular Disease, Rheumatoid Arthritis |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Rheumatology |
| Healthy: | No |
| Age Range: | 35 - 90 |
| Updated: | 7/12/2018 |
| Start Date: | April 2016 |
| End Date: | March 2021 |
| Contact: | Katherine P Liao, MD, MPH |
| Email: | kliao@partners.org |
| Phone: | 617-525-8819 |
Lipids, Inflammation, and Cardiovascular Risk in Rheumatoid Arthritis
The objective of this study is to elucidate the relationship between inflammation and
lipoprotein atherogenicity, and to determine the relative contribution of inflammation and
lipids to CV risk in RA. The central hypothesis of this study is that inflammation and
lipoprotein atherogenicity is tightly linked such that both factors are important to assess
CV risk in RA. Further, the investigators hypothesize that this relationship is obscured by a
consideration of routine lipids alone.
lipoprotein atherogenicity, and to determine the relative contribution of inflammation and
lipids to CV risk in RA. The central hypothesis of this study is that inflammation and
lipoprotein atherogenicity is tightly linked such that both factors are important to assess
CV risk in RA. Further, the investigators hypothesize that this relationship is obscured by a
consideration of routine lipids alone.
Inclusion Criteria:
- RA diagnosed by a rheumatologist
- Fulfills the 2010 American College of Rheumatology (ACR)/European League Against
Rheumatism (EULAR) Criteria for RA
- Age>35
- Active RA as defined by treating rheumatologist
- Biologic DMARD naive
Exclusion Criteria:
- Patients on statin or PCSK9 inhibitor therapy
- Corticosteroid therapy >10mg prednisone or its equivalent as a maintenance treatment
- Pregnancy
- Unstable angina (chest pain) or shortness of breath
- Severe valvular heart disease
- Myocarditis
- Pericarditis
- Asthma with active wheezing
- History of lymphoproliferative disease or melanoma (stage two or higher), active
malignancy, or cancer treatment in the last 5 years
- Active infectious disease (HIV, Tuberculosis, or Hepatitis B/C)
We found this trial at
1
site
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
Click here to add this to my saved trials
