Study of Aspirin in Patients With Vestibular Schwannoma

Inclusion Criteria:

- Radiographic diagnosis of vestibular schwannoma (NF2-associated or sporadic).

- Age≥12 years.

- Ability to provide informed consent.Pediatric patients must provide assent in addition
to their parents'/guardians' consent. Adult patients who cannot consent for themselves
will not be eligible to participate in this study.

- Ability to swallow tablets.

Exclusion Criteria:

- Inability to perform volumetric measurements of vestibular schwannoma(s).

- Inability to tolerate MRI with contrast.

- Daily use of aspirin within the last two months. Occasional use of aspirin for pain
relief is not exclusionary.

- Known allergy to aspirin.

- Impairment of gastrointestinal function or gastrointestinal disease that may
significantly alter the absorption of aspirin.

- Pregnant or lactating women.

- Patients with serious medical illnesses (e.g. severe asthma) that in the option of the
investigator could prevent participation in the trial.

- Active bleeding diathesis.

- Hydrocephalus from brainstem compression.

- Febrile illness or flu-like illness in children and adolescents less than 18 years of
age.