Longitudinal Imaging Biomarkers of Disease Progression in DLB
| Status: | Enrolling by invitation |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/13/2018 |
| Start Date: | June 25, 2018 |
| End Date: | December 2023 |
The Researchers are trying to determine the paths of change in imaging biomarkers of Dementia
with Lewy bodies (DLB) and their associations with rate of cognitive and functional decline.
with Lewy bodies (DLB) and their associations with rate of cognitive and functional decline.
The proposed project will enroll 90 subjects with probable DLB, 60 from Mayo Clinic Rochester
(MCR) and 30 from Mayo Clinic Jacksonville (MCJ). Additionally, 45 controls will be enrolled,
30 from MCR and 15 from MCJ. We will obtain up to six assessments in each subject over the 5
years of the study, baseline, six month and annually thereafter. We will follow these cohorts
with clinical and biospecimen data collection annually and once at six months, and CSF
collection annually within the guidelines of the Parkinson's Disease Biomarker's Program
(PDBP). Clinical neuroimaging will be performed annually and include: a) dopamine transporter
imaging with Ioflupane (123I) SPECT (DaTscan) as the biomarker of LBD-related loss of
dopaminergic activity, b) structural MRI AD- signature atrophy as the biomarker of AD-related
neurodegeneration, c) β-amyloid (Aβ) deposition on PET as the biomarker of Aβ pathology. In
patients from the MCR site, we will investigate AV-1451 PET. Since the specificity of AV-1451
PET is not established for tau deposition in DLB, we will investigate this biomarker in a
subset of DLB patients to determine the pattern of AV-1451 uptake compared to clinically
normal controls, and its association with atrophy, Aβ load and clinical disease progression
in DLB.
(MCR) and 30 from Mayo Clinic Jacksonville (MCJ). Additionally, 45 controls will be enrolled,
30 from MCR and 15 from MCJ. We will obtain up to six assessments in each subject over the 5
years of the study, baseline, six month and annually thereafter. We will follow these cohorts
with clinical and biospecimen data collection annually and once at six months, and CSF
collection annually within the guidelines of the Parkinson's Disease Biomarker's Program
(PDBP). Clinical neuroimaging will be performed annually and include: a) dopamine transporter
imaging with Ioflupane (123I) SPECT (DaTscan) as the biomarker of LBD-related loss of
dopaminergic activity, b) structural MRI AD- signature atrophy as the biomarker of AD-related
neurodegeneration, c) β-amyloid (Aβ) deposition on PET as the biomarker of Aβ pathology. In
patients from the MCR site, we will investigate AV-1451 PET. Since the specificity of AV-1451
PET is not established for tau deposition in DLB, we will investigate this biomarker in a
subset of DLB patients to determine the pattern of AV-1451 uptake compared to clinically
normal controls, and its association with atrophy, Aβ load and clinical disease progression
in DLB.
Inclusion Criteria:
- Diagnosis of probable DLB, at least 18 years of age, reliable informant who personally
speaks with or sees the participant at least weekly, sufficiently fluent in English,
must be willing and able to consent to the protocol and undergo up to 6 visits over 5
years, willing and able to undergo neuropsychological testing and no contraindication
to MRI imaging.
Exclusion Criteria:
- Presence of another neurologic disorder which could impact findings, such as multiple
sclerosis, brain tumors, etc., unwilling to return for follow-up yearly and undergo
neuropsychological testing and MR imaging, if undergoing Tau imaging cannot have QT
Prolongation, do not have a reliable informant.
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