Early Diagnosis and Stem Cell Transplantation for Severe Immunodeficiency Diseases
| Status: | Recruiting |
|---|---|
| Conditions: | HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any - 11 |
| Updated: | 4/2/2016 |
| Start Date: | December 2007 |
| End Date: | December 2017 |
| Contact: | Morris Kletzel, MD |
| Email: | mkletzel@childrensmemorial.org |
| Phone: | 773-880-4562 |
The hypothesis of this study is that children with severe primary immunodeficiencies will
benefit from early stem cell transplantation utilizing a reduced intensity conditioning
regimen. This regimen is associated with a low risk of complications and will lead to
correction of the underlying immunological defects.
benefit from early stem cell transplantation utilizing a reduced intensity conditioning
regimen. This regimen is associated with a low risk of complications and will lead to
correction of the underlying immunological defects.
Inclusion Criteria:
- Must show one of the following diseases:
- SCIDS
- Hyper-IgM
- Wiskott-Aldrich Syndrome
- Chediak-Higashi and Griscelli Syndromes
- X-Linked Lymphoproliferative Diseases
- IPEX Syndrome
- NEMO Syndrome
- other severe immunodeficiency diseases not stated above at the discretion of the
Principal Investigator
- Informed Consent
- Adequate Renal Function
- Adequate Liver Function
- Adequate Cardiac Function
- Adequate Pulmonary Function
- Adequate Performance Statue
- Adequate Venous Access
Exclusion Criteria:
- Patient/Family has not signed informed consent
- Patient does not have a clear diagnosis of a severe immunodeficiency disease
- A suitable donor for the patient cannot be found
- Patient is HIV positive
- Patient has active Hepatitis B
- Patient is pregnant
- Patient is considered unsuitable for transplant at the discretion of the Principal
Investigators or the medical director
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