A Study of JNJ-64565111 After Single Subcutaneous Administration at Different Injection Sites in Otherwise Healthy Overweight/Obese Adult Participants and a Study of JNJ-6456511 in Otherwise Healthy Obese Adult Participants After Multiple Dose

Inclusion Criteria:

Part A and Part B:

- If a woman, must be postmenopausal (no spontaneous menses for at least 2 years),
surgically sterile, abstinent, or, if sexually active, be practicing an effective method of
birth control before entry, throughout the study and for at least 30 days after the last
dose of study drug

Part A:

- If a woman, must have a negative serum beta human chorionic gonadotropin (hCG)
pregnancy test at screening; and a negative serum pregnancy test on Day -1 of each
treatment period

- Body mass index (weight [kilogram {kg}]/height^2 [meter {m}^2]) between 25-40 kg/m^2
(inclusive), and body weight not less than 75 kg

Part B:

- A woman must have a negative serum beta-hCG pregnancy test at screening, on Day 1, and
before each SC injection, except on Day 8(+1). On Day 8(+1), women must have a
negative serum or urine pregnancy test depending on the test performed at the
investigator's discretion

- Body mass index (weight [kg]/height^2 [m]^2) between 30-50 kg/m^2 (inclusive), and
body weight not less than 75 kg

Exclusion Criteria:

Part A and Part B:

- History of or current clinically significant medical illness including (but not
limited to) cardiac arrhythmias or other cardiac disease, hematologic disease,
coagulation disorders (including any abnormal bleeding or blood dyscrasias), lipid
abnormalities (that is [ie], fasting triglycerides greater than or equal to (>=)500
milligram per deciliter (mg/dL) and/or total cholesterol >=300 mg/dL), significant
pulmonary disease, including bronchospastic respiratory disease, diabetes mellitus,
hepatic or renal insufficiency, thyroid disease, neurologic or psychiatric disease,
infection, or any other illness that the investigator considers should exclude the
participant or that could interfere with the interpretation of the study results

- Clinically significant abnormal physical examination, vital signs, or 12 lead
electrocardiogram (ECG) at screening or at admission to the study center as deemed
appropriate by the investigator

- Clinically significant abnormal values for hematology, clinical chemistry, or
urinalysis at screening or at admission to the study center as deemed appropriate by
the investigator. Participants with serum sodium less than (<)130 milliequivalents per
liter (mEq/L) at screening should be excluded

- Known allergy to the study drug or any of the excipients of the formulation

- Donated blood or blood products or had substantial loss of blood (more than 500
milliliters [mL]) within 3 months before the first administration of study drug or
intention to donate blood or blood products during the study or within 2 months after
the completion of the study