A Study Designed to Test the Effectiveness and Safety of Treating Patients With Lacosamide for Migraine Prophylaxis

This study is for subjects who have been diagnosed with migraine for at least one year and
who are currently taking an effective abortive medication(s).

Inclusion Criteria:

- History of migraines headaches for 1 year and well documented 3 month retrospective
history of migraines.

- Experience 2-8 migraines per month but not more than 15 headache days per month. There
should be at least 48 hours of freedom between headaches.

- On effective stable abortive medication(s) for the acute treatment of migraine.

Exclusion Criteria:

- Subject in another investigational drug or device study within the last 30 days or is
currently in another investigational drug trial.

- Use of triptans or ergots for migraine abortive treatment > 2-3 days per calendar week
2 months prior to screening.

- Experience 15 or more headache days per month of any kind 2 months prior to screening.

- Has another consistent or chronic form of headache.

- Unable to stop medications, herbs, vitamins, or minerals used to prevent a migraine
from occurring.

- Pregnant or nursing women and those of child bearing potential who are not surgically
sterile, or 2 years post menopausal, or do not practice 2 combined methods of birth
control, unless sexually abstinent, during the trial.

- Significant laboratory or electrocardiograms (ECG) abnormalities

- Significant medical history including cardiovascular abnormalities.