A Study of LY573636-sodium in Patients With Metastatic Breast Cancer

Patient will receive a 2-hour intravenous infusion of study drug (LY573636-sodium) once every
28 days. Radiologic imaging scans will be performed before the first dose of study drug and
then after every other treatment. Patients will be assessed for clinical progression at every
visit and for response approximately every 56 days (every other cycle).

Inclusion Criteria:

- Received at least 2 or more prior chemotherapy regimens for metastatic breast cancer.

- Have discontinued all previous therapies for cancer, including chemotherapy,
radiotherapy, cancer-related hormonal therapy, or other investigational therapy for at
least 4 weeks. Patients who have received whole-brain radiation must wait 90 days.

Exclusion Criteria:

- Serious pre-existing medical condition.

- Have active central nervous system or leptomeningeal metastasis.

- Current hematologic malignancies, acute or chronic leukemia.

- Receiving Warfarin (Coumadin).

- Have a history of radiation therapy involving more than 25% of the bone marrow.