Body Weight, Sleep, and Heart Health
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
| Healthy: | No |
| Age Range: | 35 - 65 |
| Updated: | 2/8/2019 |
| Start Date: | May 1, 2018 |
| End Date: | May 31, 2021 |
| Contact: | Andrew W McHill, PhD |
| Email: | circadian@ohsu.edu |
| Phone: | 5033463808 |
Circadian Mechanisms of Cardiovascular Risk in Obesity
A multidisciplinary investigation examining the circadian mechanisms regulating
cardiovascular (CV) risk in obesity. Specifically, in a valid circadian protocol, the
investigators aim to study resting cardiovascular risk markers and the reactivity of
circadian rhythms in these risk markers to standardized stressors in obesity. Furthermore,
using an ingenious approach, the investigators propose to explore impairment in pre/post
synaptic function in the cardiac left ventricle.
cardiovascular (CV) risk in obesity. Specifically, in a valid circadian protocol, the
investigators aim to study resting cardiovascular risk markers and the reactivity of
circadian rhythms in these risk markers to standardized stressors in obesity. Furthermore,
using an ingenious approach, the investigators propose to explore impairment in pre/post
synaptic function in the cardiac left ventricle.
Overall, these studies will help us answer whether CV rhythms predispose obese individuals to
increased CV disease risk - particularly around the vulnerable morning period. The results
will serve as a foundation for clinical trials of appropriately timed dosing of medications
targeting aspects of the CV system in obesity that increase effectiveness while decreasing
side-effects.
increased CV disease risk - particularly around the vulnerable morning period. The results
will serve as a foundation for clinical trials of appropriately timed dosing of medications
targeting aspects of the CV system in obesity that increase effectiveness while decreasing
side-effects.
Inclusion Criteria:
- Ages 35-65
- Lean and overweight (BMI 18.5-40kg/m2)
- Habitually sedentary
Exclusion Criteria:
- History of smoking/tobacco use
- Insomnia
- Moderate to severe obstructive sleep apnea.
- Prior shift work within 6 months prior to the study.
- Prescription medications
- Drugs of abuse
- Acute, chronic, or debilitating medical condition (including diabetes, hypertension,
and metabolic syndrome)
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Phone: 503-494-2594
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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