Role of B2 Adrenergic Receptors in Labor Pain
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain, Women's Studies |
| Therapuetic Areas: | Musculoskeletal, Reproductive |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 7/20/2018 |
| Start Date: | September 2006 |
| End Date: | January 2009 |
The study aims to understand why labor is more painful for some women compared to others. The
study will study whether a woman's baseline pain sensitivity, beta2 adrenergic receptor
genotype is related to her pain in labor for the birth of a first child.
study will study whether a woman's baseline pain sensitivity, beta2 adrenergic receptor
genotype is related to her pain in labor for the birth of a first child.
Other than parity, and infant size, the etiology of the great variability in labor pain us
unknown. Previous studies have demonstrated that baseline pain sensitivity is related to
postoperative pain and narcotic requirement. We hypothesize that baseline pain sensitivity is
related to pain in labor. The study will determine baseline sensitivity to heat, cold and
pressure as measurement of pain sensitivity. Furthermore, b2 adrenergic genotype has recently
been identified as a potential determinant of pain sensitivity. The investigators will
determine whether B2 receptor haplotype is an independent predictor of pain experienced in
labor.
unknown. Previous studies have demonstrated that baseline pain sensitivity is related to
postoperative pain and narcotic requirement. We hypothesize that baseline pain sensitivity is
related to pain in labor. The study will determine baseline sensitivity to heat, cold and
pressure as measurement of pain sensitivity. Furthermore, b2 adrenergic genotype has recently
been identified as a potential determinant of pain sensitivity. The investigators will
determine whether B2 receptor haplotype is an independent predictor of pain experienced in
labor.
Inclusion Criteria:
- nulliparous women
- Third trimester of pregnancy on enrollment
Exclusion Criteria:
- Chronic Pain
- Pain medication utilization
- Large for gestational age baby
- Small for gestational age baby
- Systemic illness
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Columbia University In 1897, the university moved from Forty-ninth Street and Madison Avenue, where it...
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