Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/27/2013 |
| Start Date: | March 2006 |
| End Date: | February 2010 |
| Contact: | Laura Pare, MD, FRCSC |
| Email: | lpare@uci.edu |
| Phone: | 714-456-6966 |
The research project is designed to determine which combination of tests will enable
physicians to predict whether a patient with symptoms of normal pressure hydrocephalus (NPH)
will improve with a shunt.
Inclusion Criteria:
- Walking difficulties in both legs which has developed gradually, not explained by
other conditions, either in combination with mental impairment and urinary
incontinence
- Brain CT or MRI findings of enlarged ventricles compared to established standards
(minimum Evans ratio of 0.30 as measured by reviewing films)
- Mental impairment must be mild to moderate, emerging with or after the walking
difficulties
- Age > or = 18 years old
- MMSE (Mini-mental status exam): < or = 10
- Urinary incontinence
Exclusion Criteria:
- No or only minimal walking difficulties combined with severe dementia
- Severe medical problems with limited life expectancy (less than six months)
- Contraindications to surgery
- Lack of informed consent
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