Collection of Whole Blood Specimens in Pregnant Women

This is a prospective multicenter study in which whole blood specimens will be collected from
pregnant women scheduled for an invasive procedure.

After the standard-of-care invasive procedure is performed in accordance with the site's
clinical procedures, invasive prenatal diagnostic procedure results will also be collected.

Inclusion Criteria:

- Be 18 years of age or older at enrollment,

- Has a viable pregnancy (with documented fetal heartbeat) of at least 10 weeks, 0 days
gestation at the time of maternal specimen collection,

- Be scheduled for an invasive prenatal diagnostic procedure (either chorionic villus
sampling [CVS], amniocentesis, or percutaneous umbilical cord blood sampling
[cordocentesis]) for cytogenetic analysis of the fetus

Exclusion Criteria:

- Has a known maternal chromosomal anomaly,

- Had an invasive prenatal diagnostic procedure in the current pregnancy before maternal
specimen collection

- Has a history of transplant or malignancy, or

- Had a transfusion of blood or blood components up to 8 weeks before maternal whole
blood specimen collection

- Already participated in this study (enrolled previously).