A Clinical Registry of Orthobiologics Procedures

This Registry was designed to assure that the benefits and knowledge gained by studying
clinical outcomes associated with the use of percutaneous orthopedic procedures outweigh the
potential risks to the patients. The primary objective of this Registry is to observe the
improvements in subject-reported clinical outcomes for these procedures used to treat
musculoskeletal disorders. Secondary objectives include evaluating post-treatment
complication, adverse events, re-injections, and surgical intervention. Patients receiving
percutaneous orthopedic treatments are asked to enroll before receiving treatment and
complete a set of baseline questionnaires regarding pain and functionality of the area of the
body being treated (i.e. knee, shoulder, spine, etc). Follow-up outcomes are collected at 1
month, 3 months, 6 months, 12 months, 18 months, and annually 2-20 years post-injection.
Subjects are withdrawn from the Registry prematurely if a surgical operation occurs.

Inclusion Criteria:

- Candidates must meet ALL of the following:

1. Voluntary signature of the IRB approved Informed Consents,

2. Treated with a Regenexx procedure

3. Have a musculoskeletal condition appropriate for the procedure such as
osteoarthritis or internal joint derangement; ligament or tendon injury;
intervertebral disc degeneration; protrusion, extrusion, or annular tear; muscle
tear

Exclusion Criteria: