Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis
| Status: | Withdrawn |
|---|---|
| Conditions: | Colorectal Cancer, Cancer, Colitis, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Oncology |
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 9/19/2018 |
| Start Date: | January 20, 2017 |
| End Date: | September 12, 2018 |
This is a simple tissue collection study with no therapeutic intent. Colon tissues will be
taken from standard of care procedures. Tissues will be tested for their functions,
expression of immune co-signaling molecules and reactions to transduction with recombinant
Listeria vectors to assess effects on expression of B7-H1 and cytokines.
taken from standard of care procedures. Tissues will be tested for their functions,
expression of immune co-signaling molecules and reactions to transduction with recombinant
Listeria vectors to assess effects on expression of B7-H1 and cytokines.
Inclusion Criteria:
- Able to provide informed consent (or have consent provided through a guardian)
- No immune-modulating drug use during study or within 30 days prior to enrollment
- Having colon material collected as part of standard of care
Exclusion Criteria:
- Unable to provide informed consent (or have consent provided through a guardian)
- Not having colon material collected as part of standard of care
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