Dry Eye Symptom Relief Assessment With Use of TrueTear in a Controlled Adverse Environment

Subjects will be instructed to use the TrueTear daily for approximately 45 days with
assessments in the Controlled Adverse Environment taking place on Day 0 and Day 45. Upon
entering the CAE, participants will complete dry eye symptom questionnaires every five
minutes and will administer the device when a certain level of ocular discomfort has been
reached.

Inclusion Criteria:

- Have used and/or desired to use an artificial tear substitute for dry eye symptoms
within 6 months prior to the Screening Visit

- Normal lid/lash anatomy, blinking function and closure as determined by the
Investigator

- Literate, able to speak English, and able to complete questionnaires independently

Exclusion Criteria:

- Chronic or recurrent epistaxis, coagulation disorders or other conditions that, in the
opinion of the Investigator, may lead to risk of clinically significant increased
bleeding

- Nasal or sinus surgery (including history of application of nasal cautery) or
significant trauma to these areas

- Contact lens use within 7 days prior to the Screening Visit or anticipate the use of
contact lenses at any time during the study

- Corneal transplant in either or both eyes

- Cardiac demand pacemaker, implanted defibrillator, or other active implanted metallic
or active implanted electronic device in the head

- A woman who is pregnant, nursing an infant, or planning a pregnancy during the
duration of the study

- Currently enrolled in an investigational drug or device study or have used an
investigational drug or device within 30 days prior to the Screening Visit