A Novel Catheter Lock Solution for Treatment of Tunneled Hemodialysis Catheter-Associated Bacteremia

Inclusion Criteria:

- Adult patients who have an indwelling hemodialysis catheter for 10 or more days and
evidence of a catheter associated bloodstream infection as evidenced by
1)quantitative blood cultures obtained through the lumen of the catheter yield
concentrations of bacterial colonies that are 5 or more fold higher than peripheral
blood cultures, or 2)blood cultures obtained through the lumen of the catheter
becomes positive 2 or more hours earlier than peripheral blood cultures.

Exclusion Criteria:

- Patients will be excluded if 1) they are unable or unwilling to provide informed
consent, 2) have evidence of a complicated bacteremia such as endocarditis, septic
thrombophlebitis, septic emboli, osetoemylitis, deep seated abscesses etc 3)evidence
of an exit site infection around the catheter such as a pus pocket, drainage or
erythema. 4) patient is allergic to NAC or the proposed antibiotic (if patient is
allergic to minocycline, tigecycline will not be used). 5) patient is pregnant or
will become pregnant.