Vitamin C & Thiamine in Sepsis



Status:Recruiting
Conditions:Hospital, Hospital
Therapuetic Areas:Other
Healthy:No
Age Range:18 - 90
Updated:3/17/2019
Start Date:September 14, 2018
End Date:December 1, 2019
Contact:David Shapiro, MD
Email:DShapiro@stfranciscare.org
Phone:860-714-5237

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Trial Summary
Trial Overview
Inclusion Criteria

Vitamins B1 and C to Improve Outcomes in Patients With Severe Sepsis

Investigators propose to investigate the use of IV vitamins B1 and C in a randomized,
double-blinded, prospective trial to determine if these medications decrease mortality rates
in patients with severe sepsis or septic shock.


Patients must meet all inclusion criteria:

1. Between the ages of 18 and 90 years old

2. Have severe sepsis or septic shock. Severe sepsis and septic shock will be defined by
the Surviving Sepsis 2012 guidelines.

3. Weight more than 30 kg

4. Full code

Exclusion Criteria:

1. Not diagnosed with severe sepsis or septic shock

2. Younger than 18 or older than 90 years old

3. With a history of nephrolithiasis

4. Who are pregnant

5. Weigh less than 30 kg

6. Not located in the ICU

7. Do not resuscitate (DNR) or do not intubate (DNI), no escalation of care, or comfort
measures only (CMO)

8. Currently on dialysis
We found this trial at
1
site
Saint Francis Hospital and Medical Center
114 Woodland St
Hartford, Connecticut 06105
(860) 714-4000
Saint Francis Hospital and Medical Center Saint Francis Hospital and Medical Center has come a...
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Hartford, CT
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