Hostile Interpretation Bias Training to Treat Irritability
| Status: | Recruiting |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 13 - 17 |
| Updated: | 10/25/2018 |
| Start Date: | October 15, 2018 |
| End Date: | August 2021 |
| Contact: | Joel Stoddard, MD |
| Email: | joel.stoddard@ucdenver.edu |
| Phone: | 720-777-5702 |
Neurocognitive Targets of Hostile Interpretation Bias Training to Treat Irritability
Hostile interpretation bias may be a feature of severe, chronic irritability in children, one
of the most common psychiatric symptoms of childhood. Interpretation bias training (IBT) is a
computer-based training program that may reduce irritability in youths. This trial lays the
groundwork for a test IBT on irritability.
of the most common psychiatric symptoms of childhood. Interpretation bias training (IBT) is a
computer-based training program that may reduce irritability in youths. This trial lays the
groundwork for a test IBT on irritability.
This trial lays the foundation for a preliminary test of efficacy of IBT on irritability by
establishing IBT's neurocognitive treatment targets: hostile interpretation bias and response
in the neural threat-learning system.
The design is a single-blinded, randomized controlled trial of IBT on its targets. The study
will have four arms, with 25 participants in each arm for all four conditions of training
(active versus sham) and scanning (in MRI or out of MRI scanner). During IBT, participants
judge as happy or angry facial expressions which are on a continuum between happy and angry.
The point at which judgments shift from predominantly happy to angry on this continuum is the
indifference point. During training feedback encourages no change in the indifference point
or a change in the indifference point towards more happy judgments of ambiguous faces. A
shift in indifference point towards more benign judgments is interpreted as a reduction in
hostile interpretation.
The design will test whether active relative to sham IBT shifts the indifference point
towards more benign judgments. Neural response to active versus sham IBT will be measured in
half the sample.
establishing IBT's neurocognitive treatment targets: hostile interpretation bias and response
in the neural threat-learning system.
The design is a single-blinded, randomized controlled trial of IBT on its targets. The study
will have four arms, with 25 participants in each arm for all four conditions of training
(active versus sham) and scanning (in MRI or out of MRI scanner). During IBT, participants
judge as happy or angry facial expressions which are on a continuum between happy and angry.
The point at which judgments shift from predominantly happy to angry on this continuum is the
indifference point. During training feedback encourages no change in the indifference point
or a change in the indifference point towards more happy judgments of ambiguous faces. A
shift in indifference point towards more benign judgments is interpreted as a reduction in
hostile interpretation.
The design will test whether active relative to sham IBT shifts the indifference point
towards more benign judgments. Neural response to active versus sham IBT will be measured in
half the sample.
Inclusion Criteria:
- Adolescents seeking mental health treatment, with at least:
1. mild, clinically significant irritability, and
2. typical intellectual functioning (IQ>80)
Exclusion Criteria:
- Any of the following mental health diagnoses:
1. current post-traumatic stress
2. lifetime bipolar I or II disorder
3. lifetime cyclothymic disorder
4. lifetime psychotic disorder
5. lifetime autism spectrum disorder
- Major medical problems, including head trauma.
- MRI-specific safety exclusions for the MRI arms.
- Clinical instability.
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