Side Effects of Atropine (SEA) Study



Status:Active, not recruiting
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:21 - 30
Updated:2/14/2019
Start Date:July 23, 2018
End Date:November 30, 2019

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This study will perform several objective and subjective measurements of the eye and vision
before and after a week of using 0.01% concentration atropine drops. These measurements will
help to obtain a comprehensive understanding of the side effects of this concentration of
atropine and determine if the drops would be tolerated as a possible preventative treatment
for nearsightedness.

Atropine drops are commonly used to dilate the eye and prevent the ability to focus and also
slow the progression of nearsightedness. Low concentration (0.01%) atropine slows the
progression of myopia 60% to 83% while causing less side effects than high concentration
(1.0%) atropine though still showing an effect on pupil size and pupil response.This study is
a prospective cohort study in which several objective and subjective measurements will be
taken before and after the use of 0.01% atropine for a week to determine the effect of this
concentration on 1. vision at distance and near; 2. pupil size; 3. focusing ability,
accuracy, and change; 4. symptoms, including subjective vision, headaches, light sensitivity,
drop comfort; and 5. pressure in the eye. This will allow us to determine the effect these
drops have on the eye and whether or not patients would be willing to use them as a possible
preventative treatment for nearsightedness. The investigators expect to find that the drops
will not affect vision, will increase pupil size, decrease focusing ability and accuracy (but
not clinically meaningfully), cause some light sensitivity, and have no effect on eye
pressure. The investigators expect that patients would be willing to use these drops to
control nearsightedness even after experiencing the side effects.

Inclusion Criteria:

Exclusion Criteria:

- Outside of age range

- History of accommodative (focusing) issues or therapy
We found this trial at
1
site
Columbus, Ohio 43210
Phone: 614-247-6840
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from
Columbus, OH
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